5-methyltetrahydrofolate-homocysteine methyltransferase (Q2737583)

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mammalian protein found in Homo sapiens

• 5-methyltetrahydrofolate-homocysteine methyltransferase 1
• 5-methyltetrahydrofolate--homocysteine methyltransferase
• vitamin-B12 dependent methionine synthase
• MTR
• methionine synthase
• cobalamin-dependent methionine synthase
• MS

edit

Language	Label	Description	Also known as
English	5-methyltetrahydrofolate-homocysteine methyltransferase	mammalian protein found in Homo sapiens	5-methyltetrahydrofolate-homocysteine methyltransferase 1 5-methyltetrahydrofolate--homocysteine methyltransferase vitamin-B12 dependent methionine synthase MTR methionine synthase cobalamin-dependent methionine synthase MS

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99707

part of

Cobalamin-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Cobalamin-dependent methionine synthase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Dihydropteroate synthase-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Homocysteine-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Vitamin B12-dependent methionine synthase, activation domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Methionine synthase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Cobalamin (vitamin B12)-binding module, cap domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pterin-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cobalamin (vitamin B12)-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homocysteine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Vitamin B12-dependent methionine synthase, activation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Methionine synthase, B12-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99707

encoded by

MTR

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99707

molecular function

methyltransferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

protein binding

determination method

IPI

2 references

retrieved

8 April 2019

stated in

Crystal structure and solution characterization of the activation domain of human methionine synthase

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IPI

retrieved

8 April 2019

stated in

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IPI

methionine synthase activity

determination method

IMP

IEA

IDA

5 references

retrieved

24 April 2018

stated in

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IMP

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

24 April 2018

stated in

Human methionine synthase reductase is a molecular chaperone for human methionine synthase

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IDA

zinc ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

cobalamin binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

metal ion binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

methionine synthase activity

determination method

IBA

IDA

IEA

IMP

6 references

retrieved

8 April 2019

stated in

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

Human methionine synthase reductase is a molecular chaperone for human methionine synthase

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IBA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

cytosol

determination method

IBA

IDA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IBA

biological process

nervous system development

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

TAS

pteridine-containing compound metabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

methionine biosynthetic process

determination method

IMP

IEA

4 references

retrieved

8 April 2019

stated in

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

response to axon injury

determination method

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

cellular amino acid biosynthetic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

cobalamin metabolic process

determination method

IMP

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

TAS

retrieved

8 April 2019

stated in

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IMP

cellular response to nitric oxide

determination method

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

axon regeneration

determination method

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

cell metabolism

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

methylation

determination method

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99707&geneProductId=UniProtKB:Q99707

determination method

IEA

sulfur amino acid metabolic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

TAS

methylation

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99707

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99707

determination method

IEA

EC enzyme number

2.1.1.13

0 references

Gene Atlas image

PBB GE MTR 203774 at fs.png
732 × 530; 12 KB

0 references

has part(s)

Vitamin B12-dependent methionine synthase, activation domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Cobalamin (vitamin B12)-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Pterin-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Homocysteine-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Cobalamin (vitamin B12)-binding module, cap domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

Methionine synthase, B12-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99707

different from

MTR

1 reference

imported from Wikimedia project

Polish Wikipedia

Wikimedia import URL

https://pl.wikipedia.org/w/index.php?title=Metylotransferaza_homocysteinowa&oldid=54456008

Identifiers

RefSeq protein ID

NP_000245

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

NP_001278868

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

NP_001278869

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

XP_005273198

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

XP_006711833

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

XP_011542496

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

XP_016856818

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

XP_016856819

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4548

UniProt protein ID

Q99707

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99707

Ensembl protein ID

ENSP00000355536

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000355536

ENSP00000441845

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000441845

ENSP00000355535

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000355535

ENSP00000498963

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000498963

ENSP00000498393

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000498393

Freebase ID

/m/08f42l

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

80315684

0 references

2910130079

0 references

OpenAlex ID

C80315684

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

2O2K

1 reference

stated in

UniProt

UniProt protein ID

Q99707

retrieved

9 August 2016

language of work or name

English

4CCZ

1 reference

stated in

UniProt

UniProt protein ID

Q99707

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(17 entries)

edit

• bswiki MTR (gen)
• cawiki Metionina sintasa
• cywiki MTR
• dewiki Methionin-Synthase
• enwiki Methionine synthase
• eswiki Metionina sintasa
• fiwiki Metioniinisyntaasi
• frwiki Méthionine synthase
• hewiki מתיונין סינתאז
• huwiki Metionin-szintáz
• itwiki Metionina sintasi
• jawiki 5-メチルテトラヒドロ葉酸-ホモシステインメチルトランスフェラーゼ
• plwiki Metylotransferaza homocysteinowa
• shwiki Metionin sintaza
• srwiki Metionin sintaza
• ttwiki MTR
• ukwiki MTR

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q2737583&oldid=2022903979"