Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus (Q27469559)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9658124%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

title

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus (English)

1 reference

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13 November 2019

0 references

1 reference

1 reference

Raffaele De Francesco

7

1 reference

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13 November 2019

author name string

P Gallinari

1

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13 November 2019

D Brennan

2

1 reference

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13 November 2019

C Nardi

3

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13 November 2019

M Brunetti

4

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13 November 2019

L Tomei

5

1 reference

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13 November 2019

C Steinkühler

6

1 reference

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13 November 2019

language of work or name

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1 August 1998

1 reference

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13 November 2019

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13 November 2019

volume

72

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13 November 2019

page(s)

6758-6769

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13 November 2019

issue

8

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describes a project that uses

13 November 2019

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC109884/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

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Mutational analysis of the hepatitis C virus RNA helicase

21 March 2017

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Refined X-ray crystallographic structure of the poliovirus 3C gene product

21 March 2017

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A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein

21 March 2017

1 reference

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Structure of the hepatitis C virus RNA helicase domain

21 March 2017

1 reference

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Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

21 March 2017

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The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme

21 March 2017

1 reference

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Virus-encoded RNA helicases

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The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition

21 March 2017

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The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

21 March 2017

1 reference

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 March 2017

1 reference

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The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

21 March 2017

1 reference

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Activity of purified hepatitis C virus protease NS3 on peptide substrates

21 March 2017

1 reference

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Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

21 March 2017

1 reference

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Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA

21 March 2017

1 reference

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Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease

21 March 2017

1 reference

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Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

21 March 2017

1 reference

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Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

21 March 2017

1 reference

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Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism

21 March 2017

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Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites

21 March 2017

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Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

21 March 2017

1 reference

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Biosynthesis and biochemical properties of the hepatitis C virus core protein

21 March 2017

1 reference

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Kinetic and structural analyses of hepatitis C virus polyprotein processing

21 March 2017

1 reference

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Hepatitis C virus polyprotein processing: kinetics and mutagenic analysis of serine proteinase-dependent cleavage

21 March 2017

1 reference

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Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

21 March 2017

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Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing

21 March 2017

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An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

21 March 2017

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Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

21 March 2017

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A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

21 March 2017

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NS3 is a serine protease required for processing of hepatitis C virus polyprotein

21 March 2017

1 reference

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Expression and identification of hepatitis C virus polyprotein cleavage products

21 March 2017

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Structure and organization of the hepatitis C virus genome isolated from human carriers

21 March 2017

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Internal ribosome entry site within hepatitis C virus RNA

21 March 2017

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

21 March 2017

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21 March 2017

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Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis

21 March 2017

1 reference

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Genetic organization and diversity of the hepatitis C virus

21 March 2017

1 reference

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Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

21 March 2017

1 reference

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A second hepatitis C virus-encoded proteinase

21 March 2017

1 reference

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C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

7 April 2017

1 reference

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Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

7 April 2017

1 reference

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Establishment of an in vitro assay to characterize hepatitis C virus NS3-4A protease trans-processing activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Bacterial expression and analysis of cleavage activity of HCV serine proteinase using recombinant and synthetic substrate.

29 September 2017

1 reference

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To C or not to C: these are the questions.

29 September 2017

1 reference

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Product inhibition of the hepatitis C virus NS3 protease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Identification of the protease domain in NS3 of hepatitis C virus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

A zinc binding site in viral serine proteinases

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Processing of hepatitis C viral polyprotein in Escherichia coli

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Processing of the hepatitis C virus precursor protein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

DNA helicase activity of the hepatitis C virus nonstructural protein 3.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

High-level expression of soluble protein in Escherichia coli using a His6-tag and maltose-binding-protein double-affinity fusion system.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Complete 5' noncoding region is necessary for the efficient internal initiation of hepatitis C virus RNA.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Analysis of NS3-mediated processing of the hepatitis C virus non-structural region in vitro

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

A novel sequence found at the 3' terminus of hepatitis C virus genome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109884

Hepatitis C and hepatocellular carcinoma

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9658124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9658124%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference