Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase (Q27478443)

2

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K Yasargil

3

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J Mous

4

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H Jacobsen

Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site

5

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publication date

January 1995

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published in

Journal of Virology

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volume

69

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page(s)

198-205

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issue

1

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cites work

1 reference

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21 March 2017

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Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

21 March 2017

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Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus

21 March 2017

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Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

21 March 2017

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Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites

21 March 2017

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Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

21 March 2017

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Biosynthesis and biochemical properties of the hepatitis C virus core protein

21 March 2017

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Kinetic and structural analyses of hepatitis C virus polyprotein processing

21 March 2017

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NS3 is a serine protease required for processing of hepatitis C virus polyprotein

21 March 2017

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Expression and identification of hepatitis C virus polyprotein cleavage products

21 March 2017

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Flavivirus genome organization, expression, and replication

21 March 2017

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Expression of processed core protein of hepatitis C virus in mammalian cells

21 March 2017

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Flavivirus enzyme-substrate interactions studied with chimeric proteinases: identification of an intragenic locus important for substrate recognition

21 March 2017

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Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells

21 March 2017

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Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

21 March 2017

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 March 2017

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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis

21 March 2017

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Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis

21 March 2017

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Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

21 March 2017

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Hepatitis C virus infection is associated with the development of hepatocellular carcinoma

21 March 2017

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Serine Proteases: Structure and Mechanism of Catalysis

21 March 2017

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At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide

21 March 2017

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Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome

7 April 2017

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A second hepatitis C virus-encoded proteinase

7 April 2017

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Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

7 April 2017

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Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses

7 April 2017

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Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses

7 April 2017

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Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups

7 April 2017

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Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease

7 April 2017

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Mutagenesis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage sites: effects on cleavage efficiency and polyprotein processing

7 April 2017

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Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

29 September 2017

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Mutagenesis of the yellow fever virus NS2A/2B cleavage site: effects on proteolytic processing, viral replication, and evidence for alternative processing of the NS2A protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188564

Mapping the active site of papain with the aid of peptide substrates and inhibitors

29 September 2017

1 reference

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Gene mapping and positive identification of the non-structural proteins NS2A, NS2B, NS3, NS4B and NS5 of the flavivirus Kunjin and their cleavage sites

29 September 2017

1 reference

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Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis

29 September 2017

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Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites

29 September 2017

1 reference

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Molecular genetics of pestiviruses

29 September 2017

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Determinants of substrate recognition by poliovirus 2A proteinase

29 September 2017

1 reference

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Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease

29 September 2017

1 reference

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Characterization of hepatitis C virus structural proteins with a recombinant baculovirus expression system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188564

Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector.

2 June 2018

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Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma

2 June 2018

1 reference

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Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population

2 June 2018

1 reference

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Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188564

Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188564

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188564

Iron increases ethanol toxicity in rat liver

27 November 2018

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PubMed

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