Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors (Q27480926)

1

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Wendy Mostmans

2

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Ludo M M Quirynen

3

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Liesbet van der Helm

4

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Carlo W Boutton

5

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Anne-Stéphanie Rueff

6

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Erna Cleiren

7

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Dominique Surleraux

9

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Origène Nyanguile

10

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Kenneth A Simmen

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

11

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publication date

July 2007

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published in

Journal of Virology

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volume

81

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issue

13

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page(s)

6909-19

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cites work

1 reference

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Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro

20 March 2017

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Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay

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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

20 March 2017

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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

20 March 2017

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

20 March 2017

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

20 March 2017

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A mechanism for initiating RNA-dependent RNA polymerization

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

20 March 2017

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Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli

20 March 2017

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Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

20 March 2017

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20 March 2017

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7 April 2017

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3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

29 September 2017

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Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

29 September 2017

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HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase

29 September 2017

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Challenges and successes in developing new therapies for hepatitis C.

29 September 2017

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

29 September 2017

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29 September 2017

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Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

29 September 2017

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Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

29 September 2017

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Recent developments in target identification against hepatitis C virus

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Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.

29 September 2017

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

29 September 2017

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Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

29 September 2017

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

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Optimal therapy of hepatitis C.

29 September 2017

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