Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo (Q27482438)

1

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R Leduc

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L Thomas

3

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J Thorner

4

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H L Gibson

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A J Brake

6

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P J Barr

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G Thomas

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein

8

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language of work or name

English

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publication date

December 1990

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published in

Journal of Cell Biology

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volume

111

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issue

6 Pt 2

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page(s)

2851-9

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cites work

1 reference

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Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

20 March 2017

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Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution

20 March 2017

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Measurement of protein using bicinchoninic acid

20 March 2017

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Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor

20 March 2017

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Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease

20 March 2017

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Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands

20 March 2017

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Insulin biosynthesis: evidence for a precursor

20 March 2017

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Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases

20 March 2017

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Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae

20 March 2017

1 reference

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Neurotrophin-3: a neurotrophic factor related to NGF and BDNF

20 March 2017

1 reference

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Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides

20 March 2017

1 reference

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Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen

20 March 2017

1 reference

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Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cells

7 April 2017

1 reference

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Human beta-nerve growth factor gene sequence highly homologous to that of mouse

29 September 2017

1 reference

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Polyprotein gene expression: generation of diversity of neuroendocrine peptides

29 September 2017

1 reference

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Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

29 September 2017

1 reference

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Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Secretion and autoproteolytic maturation of subtilisin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Cloning and sequence analysis of simian transforming growth factor-beta cDNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Constitutive and regulated secretion of proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Enzymes required for yeast prohormone processing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Gene transfer techniques to study neuropeptide processing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide

29 September 2017

1 reference

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Mutations within the proteolytic cleavage site of the Rous sarcoma virus glycoprotein that block processing to gp85 and gp37

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Amino-terminal deletion mutants of the Rous sarcoma virus glycoprotein do not block signal peptide cleavage but can block intracellular transport

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Surface expression of viral glycoproteins is polarized in epithelial cells infected with recombinant vaccinia viral vectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Cellular and molecular biology of neuropeptide processing and packaging

29 September 2017

1 reference

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Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

A chromosomal gene required for killer plasmid expression, mating, and spore maturation in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Evidence for pro-β-nerve growth factor, a biosynthetic precursor to β-nerve growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

In VitroProcessing of Proopiocortin by Membrane-Associated and Soluble Converting Enzyme Activities from Rat Intermediate Lobe Secretory Granules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Role of glandular kallikreins as growth factor processing enzymes: structural and evolutionary considerations

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

In vitro processing of pro-subtilisin produced in Escherichia coli.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Purification and characterization of a paired basic residue-specific prohormone-converting enzyme from bovine pituitary neural lobe secretory vesicles.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Use of vaccinia virus as a neuropeptide expression vector

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

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2 June 2018

1 reference

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Pathways of protein secretion in eukaryotes

2 June 2018

1 reference

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Intracellular targeting and structural conservation of a prohormone-processing endoprotease

2 June 2018

1 reference

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The role of paired basic amino acids in mediating proteolytic cleavage of prosomatostatin. Analysis using site-directed mutagenesis

2 June 2018

1 reference

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Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2116363

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

2 June 2018

1 reference

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2 June 2018

1 reference

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Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

2 June 2018

1 reference

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A single gene encodes multiple neuropeptides mediating a stereotyped behavior

2 June 2018

1 reference

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1 reference

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1 reference

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The in vitro processing of the NGF precursors by the gamma-subunit of the 7S NGF complex

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Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells

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Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells

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