Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 (Q27487389)

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English	Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479	scientific article

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scholarly article

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Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 (English)

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Hepatitis C virus

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Samir Ali

1

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Vincent Leveque

2

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Sophie Le Pogam

3

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Han Ma

4

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Friederike Philipp

5

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Nicole Inocencio

6

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Mark Smith

7

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Andre Alker

8

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Hyunsoon Kang

9

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Isabel Najera

10

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Klaus Klumpp

11

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Julian Symons

12

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Nick Cammack

13

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Wen-Rong Jiang

14

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language of work or name

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publication date

December 2008

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Antimicrobial Agents and Chemotherapy

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52

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4356-69

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12

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The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

1 reference

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Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

1 reference

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Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

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In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

1 reference

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1 reference

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