Complement Protein C1q Reduces the Stoichiometric Threshold for Antibody-Mediated Neutralization of West Nile Virus (Q27490423)

8

Theodore C Pierson

0 references

Daved H. Fremont

6

Daved H Fremont

0 references

Steevenson Nelson

2

Steevenson Nelson

0 references

Syd Johnson

5

Syd Johnson

0 references

Sergey Gorlatov

4

Sergey Gorlatov

0 references

Erin Mehlhop

1

Erin Mehlhop

0 references

Christiane A Jost

3

Complement modulates pathogenesis and antibody-dependent neutralization of West Nile virus infection through a C5-independent mechanism

Christiane A Jost

0 references

publication date

22 October 2009

0 references

published in

Cell Host & Microbe

0 references

volume

6

0 references

issue

4

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page(s)

381-91

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cites work

1 reference

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Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

20 March 2017

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Dengue in Vietnamese Infants—Results of Infection‐Enhancement Assays Correlate with Age‐Related Disease Epidemiology, and Cellular Immune Responses Correlate with Disease Severity

20 March 2017

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Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization

20 March 2017

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Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II

20 March 2017

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Role of dendritic cells in antibody-dependent enhancement of dengue virus infection

20 March 2017

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Complement Protein C1q Inhibits Antibody-Dependent Enhancement of Flavivirus Infection in an IgG Subclass-Specific Manner

20 March 2017

1 reference

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The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus Infection

20 March 2017

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Infection-Enhancing and -Neutralizing Activities of Mouse Monoclonal Antibodies against Dengue Type 2 and 4 Viruses Are Controlled by Complement Levels

20 March 2017

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Induction of Epitope-Specific Neutralizing Antibodies against West Nile Virus

20 March 2017

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Defining Limits of Treatment with Humanized Neutralizing Monoclonal Antibody for West Nile Virus Neurological Infection in a Hamster Model

20 March 2017

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Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis

20 March 2017

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Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein

20 March 2017

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Crystal Structure of the West Nile Virus Envelope Glycoprotein

20 March 2017

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Cryptic Properties of a Cluster of Dominant Flavivirus Cross-Reactive Antigenic Sites

20 March 2017

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Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

20 March 2017

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Crystal Structure of West Nile Virus Envelope Glycoprotein Reveals Viral Surface Epitopes

20 March 2017

1 reference

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Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus

20 March 2017

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Protective immune responses against West Nile virus are primed by distinct complement activation pathways

20 March 2017

1 reference

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West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and Infection

20 March 2017

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Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus

20 March 2017

1 reference

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Complement activation is required for induction of a protective antibody response against West Nile virus infection

20 March 2017

1 reference

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Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

20 March 2017

1 reference

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B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.

20 March 2017

1 reference

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Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein

20 March 2017

1 reference

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The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

20 March 2017

1 reference

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Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q

20 March 2017

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Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses

20 March 2017

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C1q: structure, function, and receptors

20 March 2017

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Global spread and persistence of dengue

20 March 2017

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Fcgamma receptors as regulators of immune responses

7 April 2017

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Prospects for a dengue virus vaccine

7 April 2017

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Structural basis of West Nile virus neutralization by a therapeutic antibody

7 April 2017

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A structural perspective of the flavivirus life cycle

7 April 2017

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Neutralization and antibody-dependent enhancement of dengue viruses

7 April 2017

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7 April 2017

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Evidence That Maternal Dengue Antibodies Are Important in the Development of Dengue Hemorrhagic Fever in Infants

7 April 2017

1 reference

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Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement

7 April 2017

1 reference

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The immunoglobulin constant region contributes to affinity and specificity

29 September 2017

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The long-term outcomes of human West Nile virus infection

29 September 2017

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Humanized monoclonal antibody against West Nile virus envelope protein administered after neuronal infection protects against lethal encephalitis in hamsters.

29 September 2017

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Enhancement of neutralizing activity of influenza virus-specific antibodies by serum components

29 September 2017

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A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection

29 September 2017

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Characterization of neutralizing antibodies to West Nile virus

29 September 2017

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An infectious West Nile virus that expresses a GFP reporter gene.

29 September 2017

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The complement system in regulation of adaptive immunity

29 September 2017

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Antigenic structure of flavivirus proteins

29 September 2017

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Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice

29 September 2017

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29 September 2017

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The role of complement in innate and adaptive immunity

29 September 2017

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Antibody prophylaxis and therapy for flavivirus encephalitis infections.

29 September 2017

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Complement component C1q enhances the biological activity of influenza virus hemagglutinin-specific antibodies depending on their fine antigen specificity and heavy-chain isotype

29 September 2017

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29 September 2017

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Neutralizing F(ab')2 fragments of protective monoclonal antibodies to yellow fever virus (YF) envelope protein fail to protect mice against lethal YF encephalitis

29 September 2017

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29 September 2017

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29 September 2017

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Complement components required for virus neutralization by early immunoglobulin antibody

29 September 2017

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Neutralization of sensitized virus by purified components of complement

29 September 2017

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Immunoglobulin G: functional sites

29 September 2017

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Profiles of antibody-dependent enhancement of dengue virus type 2 infection

29 September 2017

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Immune response in rabbits to virion and nonvirion antigens of the Flavivirus kunjin

29 September 2017

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A multi-hit model for the neutralization of animal viruses

29 September 2017

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Fc receptor but not complement binding is important in antibody protection against HIV.

29 September 2017

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Flavivirus Infection Enhancement in Macrophages: Radioactive and Biological Studies on the Effect of Antibody on Viral Fate

2 June 2018

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Neutralization of sensitized virus by the fourth component of complement

2 June 2018

1 reference

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Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782387

Interactions of a nonneutralizing IgM antibody and complement in parainfluenza virus neutralization

2 June 2018

1 reference

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The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782387

A detailed mutagenesis study of flavivirus cross-reactive epitopes using West Nile virus-like particles

2 June 2018

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Complement can neutralize HIV-1 plasma virus by a C5-independent mechanism

27 November 2018

1 reference

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Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19837377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The binding site for C1q on IgG

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19837377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHOM.2009.09.003

1 reference

2370959

2370959

1 reference

1 reference

1 reference