Adeno-associated virus: from defective virus to effective vector (Q27498163)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

review article

1 reference

title

Adeno-associated virus: from defective virus to effective vector (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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0 references

1 reference

3 November 2019

Manuel A F V Gonçalves

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

author name string

Manuel AFV Gonçalves

series ordinal

1

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Manuel A F V Gonçalves

series ordinal

1

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language of work or name

English

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publication date

6 May 2005

2 references

3 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

3 references

3 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

43

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Creative Commons Attribution 2.0 Generic

11 January 2020

issue

1

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copyright license

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https://scigraph.springernature.com/pub.10.1186/1743-422x-2-43

3 November 2019

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Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity

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Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

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Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

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Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

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Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA

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Parvovirus replication

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Site-specific integration by adeno-associated virus

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ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

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Altering the genome by homologous recombination

20 March 2017

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Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity

20 March 2017

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Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.

29 September 2017

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Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes

29 September 2017

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Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

29 September 2017

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Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction

29 September 2017

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Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

29 September 2017

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Adeno-associated virus site-specific integration and AAVS1 disruption

29 September 2017

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Adeno-associated virus vectors integrate at chromosome breakage sites

29 September 2017

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Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors

29 September 2017

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29 September 2017

AAV-based gene transfer

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Identification of PDGFR as a receptor for AAV-5 transduction

29 September 2017

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Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA.

29 September 2017

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From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

29 September 2017

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AAV serotype 2 vectors preferentially integrate into active genes in mice

29 September 2017

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Consequences of DNA-dependent protein kinase catalytic subunit deficiency on recombinant adeno-associated virus genome circularization and heterodimerization in muscle tissue

29 September 2017

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

29 September 2017

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A novel gene expression control system and its use in stable, high-titer 293 cell-based adeno-associated virus packaging cell lines

29 September 2017

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Insect cells as a factory to produce adeno-associated virus type 2 vectors

29 September 2017

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Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2.

29 September 2017

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A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.

29 September 2017

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Second generation adeno-associated virus type 2-based gene therapy systems with the potential for preferential integration into AAVS1.

29 September 2017

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The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity

29 September 2017

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Recombinant AAV-mediated gene delivery using dual vector heterodimerization.

29 September 2017

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Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome.

29 September 2017

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Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat

29 September 2017

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A viral phospholipase A2 is required for parvovirus infectivity

29 September 2017

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Generation of a high-capacity hybrid vector: packaging of recombinant adenoassociated virus replicative intermediates in adenovirus capsids overcomes the limited cloning capacity of adenoassociated virus vectors

29 September 2017

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A single-step affinity column for purification of serotype-5 based adeno-associated viral vectors.

29 September 2017

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Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

29 September 2017

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DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids

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Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle

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29 September 2017

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29 September 2017

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Inhibition of S-phase progression by adeno-associated virus Rep78 protein is mediated by hypophosphorylated pRb

29 September 2017

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Mechanism of Rep-mediated adeno-associated virus origin nicking

29 September 2017

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Characteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcription-competent environment

29 September 2017

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Ubiquitous human adeno-associated virus type 2 autonomously replicates in differentiating keratinocytes of a normal skin model

29 September 2017

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DNA sequence motifs which direct adeno-associated virus site-specific integration in a model system

29 September 2017

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Adeno-associated virus site-specifically integrates into a muscle-specific DNA region

29 September 2017

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Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination

29 September 2017

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Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors

29 September 2017

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Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation

29 September 2017

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Dynamin is required for recombinant adeno-associated virus type 2 infection

29 September 2017

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Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.

29 September 2017

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Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.

29 September 2017

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High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.

29 September 2017

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Cystic fibrosis and the salt controversy

29 September 2017

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Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.

29 September 2017

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AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection

29 September 2017

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Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

29 September 2017

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High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus

29 September 2017

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Adeno-associated virus vectors can be efficiently produced without helper virus

29 September 2017

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Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector.

29 September 2017

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The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity

29 September 2017

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Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection

29 September 2017

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Role for highly regulated rep gene expression in adeno-associated virus vector production

29 September 2017

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Binding sites for adeno-associated virus Rep proteins within the human genome.

29 September 2017

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Subcellular compartmentalization of adeno-associated virus type 2 assembly

29 September 2017

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The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection

29 September 2017

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Biology of adeno-associated virus.

29 September 2017

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A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease

29 September 2017

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The recombination signals for adeno-associated virus site-specific integration

29 September 2017

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In vivo model of adeno-associated virus vector persistence and rescue

29 September 2017

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Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats

29 September 2017

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Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein

29 September 2017

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DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.

29 September 2017

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Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein

29 September 2017

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Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

A Human Parvovirus, Adeno-Associated Virus, as a Eucaryotic Vector: Transient Expression and Encapsidation of the Procaryotic Gene for Chloramphenicol Acetyltransferase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Separation of Two Types of Adeno-Associated Virus Particles Containing Complementary Polynucleotide Chains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Self-complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

DNA amplification of adeno-associated virus as a response to cellular genotoxic stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Factors that bind to adeno-associated virus terminal repeats.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Targeted integration of adeno-associated virus (AAV) into human chromosome 19

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Assembly of viruslike particles by recombinant structural proteins of adeno-associated virus type 2 in insect cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Human gene targeting by viral vectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Quantitative analysis of the packaging capacity of recombinant adeno-associated virus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

A novel adenovirus-adeno-associated virus hybrid vector that displays efficient rescue and delivery of the AAV genome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Molecular structure of adeno-associated virus variant DNA

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Mutagenesis of an AUG codon in the adeno-associated virus rep gene: effects on viral DNA replication

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Improved transduction of primary murine hepatocytes by recombinant adeno-associated virus 2 vectors in vivo

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Pathways of removal of free DNA vector ends in normal and DNA-PKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

A biochemical characterization of the adeno-associated virus Rep40 helicase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Real-time single-molecule imaging of the infection pathway of an adeno-associated virus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Posttranslational modifications of recombinant myotube-synthesized human factor IX.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

Novel tools for production and purification of recombinant adenoassociated virus vectors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1131931

27 November 2018

Identifiers

DOI

10.1186/1743-422X-2-43

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 January 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1743-422x-2-43

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15877812%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

2 references