Mannose-ethanolamine phosphotransferase MCD4 YKL165C (Q27548942)

Alkaline-phosphatase-like, core domain superfamily

1 reference

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.6.1.1

retrieved

2 October 2019

hierarchical database ID heuristic

membrane protein

1 reference

inferred from GOA cell component → membrane

Sulfatase, N-terminal domain, protein family

1 reference

inferred from protein domain or family

GPI ethanolamine phosphate transferase 1, C-terminal domain, protein family

1 reference

inferred from protein domain or family

GPI ethanolamine phosphate transferase 1, N-terminal domain, protein family

1 reference

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

sulfuric ester hydrolase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

mannose-ethanolamine phosphotransferase activity

3 references

31 January 2018

Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

mannose-ethanolamine phosphotransferase activity

4 references

14 February 2019

In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

A novel vacuolar protein encoded by SSU21 / MCD4 is involved in cell wall integrity in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

Correct GPI-anchor synthesis is required for the incorporation of endoglucanase/glucanosyltransferase Bgl2p into the Saccharomyces cerevisiae cell wall

fungal-type cell wall

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

endoplasmic reticulum membrane

IBA

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

2 references

endoplasmic reticulum

3 references

14 February 2019

14 February 2019

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

integral component of membrane

HDA

3 references

14 January 2019

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

GPI anchor biosynthetic process

biological process

5 references

31 January 2018

Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

31 January 2018

Correct GPI-anchor synthesis is required for the incorporation of endoglucanase/glucanosyltransferase Bgl2p into the Saccharomyces cerevisiae cell wall

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

IDA

cell wall organization

1 reference

14 February 2019

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36051&geneProductId=UniProtKB:P36051

1 reference

14 February 2019

ATP uptake in the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

GPI anchor biosynthetic process

IDA

6 references

14 February 2019

In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

Correct GPI-anchor synthesis is required for the incorporation of endoglucanase/glucanosyltransferase Bgl2p into the Saccharomyces cerevisiae cell wall

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36051

IBA

has part(s)

Sulfatase, N-terminal

1 reference

GPI ethanolamine phosphate transferase 1, C-terminal

1 reference

GPI ethanolamine phosphate transferase 1, N-terminal

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Transporter Classification Database ID

1 reference

20 March 2022

9.A.6.1.1

2 references

Transporter Classification database

retrieved

13 March 2020