Translation initiation factor eIF5 YPR041W (Q27550031)

Translation initiation factor IF2/IF5, zinc-binding

1 reference

Armadillo-type fold

1 reference

W2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Translation initiation factor IF2/IF5, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

translation initiation factor activity

5 references

1 January 2018

Eukaryotic translation initiation factor 5 from Saccharomyces cerevisiae. Cloning, characterization, and expression of the gene encoding the 45,346-Da protein.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

Development and characterization of a reconstituted yeast translation initiation system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

GDP-dissociation inhibitor activity

IMP

translation initiation factor binding

4 references

9 May 2019

Efficient incorporation of eukaryotic initiation factor 1 into the multifactor complex is critical for formation of functional ribosomal preinitiation complexes in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Efficient incorporation of eukaryotic initiation factor 1 into the multifactor complex is critical for formation of functional ribosomal preinitiation complexes in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

The binding mechanism of eIF2β with its partner proteins, eIF5 and eIF2Bε.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

GTPase activator activity

6 references

9 May 2019

Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

The binding mechanism of eIF2β with its partner proteins, eIF5 and eIF2Bε.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

GTPase activator activity

1 reference

1 January 2018

Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

translation initiation factor activity

ISS

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

8 April 2019

Development and characterization of a reconstituted yeast translation initiation system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

translation initiation factor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Development and characterization of a reconstituted yeast translation initiation system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

GDP-dissociation inhibitor activity

IBA

3 references

9 May 2019

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

eukaryotic initiation factor eIF2 binding

IBA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

cytosolic small ribosomal subunit

1 reference

9 May 2019

Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

eukaryotic 48S preinitiation complex

IPI

1 reference

9 May 2019

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

formation of cytoplasmic translation initiation complex

IBA

biological process

1 reference

8 April 2019

Development and characterization of a reconstituted yeast translation initiation system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

regulation of translational initiation

4 references

1 January 2018

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 January 2018

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

mature ribosome assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

negative regulation of translational initiation

IMP

positive regulation of GTPase activity

IMP

IGI

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

regulation of catalytic activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

regulation of translational initiation

3 references

9 May 2019

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

9 May 2019

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

formation of translation preinitiation complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38431

1 reference

Translation initiation factor IF2/IF5

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference