U4/U6-U5 snRNP complex subunit PRP8 YHR165C (Q27551093)

Ribonuclease H-like superfamily

1 reference

RNA recognition motif, spliceosomal PrP8, protein family

1 reference

PROCT domain, protein family

1 reference

PRP8 domain IV core domain, protein family

1 reference

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding domain, protein family

1 reference

PRO8NT domain, protein family

1 reference

PROCN domain, protein family

1 reference

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain, protein family

1 reference

MPN domain, protein family

1 reference

JAB1/MPN/MOV34 metalloenzyme domain family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

27 March 2018

Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

27 March 2018

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

1 reference

27 March 2018

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

pre-mRNA intronic binding

1 reference

27 March 2018

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

1 reference

27 March 2018

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

second spliceosomal transesterification activity

1 reference

27 March 2018

Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

12 references

9 May 2019

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Crystal structure of Prp8 reveals active site cavity of the spliceosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

1 reference

9 May 2019

Global analysis of yeast mRNPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

3 references

27 March 2018

Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

27 March 2018

The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

27 March 2018

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334

U4/U6 x U5 tri-snRNP complex

3 references

9 May 2019

Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

catalytic step 2 spliceosome

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

4 references

9 May 2019

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

mRNA 3'-splice site recognition

IEA

1 reference

9 May 2019

Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

mRNA splicing, via spliceosome

IEA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

spliceosomal tri-snRNP complex assembly

IEA

3 references

9 May 2019

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

mRNA 5'-splice site recognition

IBA

1 reference

9 May 2019

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334

1 reference

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding

1 reference

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding

1 reference

RNA recognition motif, spliceosomal PrP8

1 reference

PROCN domain

1 reference

JAB1/MPN/MOV34 metalloenzyme domain

1 reference

PROCT domain

1 reference

PRO8NT domain

1 reference

MPN domain

1 reference