Chromatin-silencing protein SIR3 YLR442C (Q27551620)

http://www.ebi.ac.uk/interpro/protein/P06701

Bromo adjacent homology (BAH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

single-stranded DNA binding

1 reference

9 May 2019

Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

1 reference

9 May 2019

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

double-stranded DNA binding

IDA

1 reference

9 May 2019

Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

4 references

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

identical protein binding

IPI

3 references

9 May 2019

Defining the budding yeast chromatin-associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

DNA replication origin binding

IPI

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

1 reference

9 May 2019

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

chromatin silencing complex

IDA

1 reference

9 May 2019

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

1 reference

9 May 2019

The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

nuclear origin of replication recognition complex

IDA

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

silent mating-type cassette heterochromatin assembly

biological process

3 references

9 May 2019

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

9 May 2019

Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

nuclear-transcribed mRNA catabolic process, non-stop decay

IGI

1 reference

9 May 2019

A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

transcription, DNA-templated

IMP

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.

IEA

heterochromatin assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

regulation of transcription, DNA-templated

IMP

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

double-strand break repair via nonhomologous end joining

IEA

1 reference

9 May 2019

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

establishment of protein-containing complex localization to telomere

IMP

1 reference

9 May 2019

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06701

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

DNA replication initiation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

mitotic DNA replication checkpoint signaling

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06701&geneProductId=UniProtKB:P06701

Bromo adjacent homology (BAH) domain

has part(s)

1 reference

stated in

InterPro Release 71.0