Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase (Q27617894)

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4 December 2019

title

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase (English)

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4 December 2019

6

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4 December 2019

author name string

A M Aronov

1

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4 December 2019

S Suresh

2

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4 December 2019

F S Buckner

3

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4 December 2019

W C Van Voorhis

4

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4 December 2019

C L Verlinde

5

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4 December 2019

W G Hol

7

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4 December 2019

M H Gelb

8

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4 December 2019

language of work or name

English

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publication date

1 April 1999

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Proceedings of the National Academy of Sciences of the United States of America

4 December 2019

published in

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4 December 2019

volume

96

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4 December 2019

page(s)

4273-4278

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4 December 2019

issue

8

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Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site

4 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Raster3D: photorealistic molecular graphics

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

20 March 2017

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Metabolic compartmentation in African trypanosomes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Human African trypanosomiasis: an emerging public health crisis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

The treatment of human African trypanosomiasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

QXP: powerful, rapid computer algorithms for structure-based drug design.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Cultivation of Trypanosoma brucei sspp. in semi-defined and defined media.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16322

Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Refined 3.2 A structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: structure, catalytic mechanism and targeted inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

N6-Substituted adenosines. Synthesis, biological activity, and some structure-activity relations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4273

A novel method for phosphorylation of nucleosides to 5′-nucleotides

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10200252

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12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.96.8.4273

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4 December 2019

0 references

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4 December 2019

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