The crystal structure of α-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode (Q27617975)

2

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F Nastri

3

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S Galdiero

4

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R Della Morte

5

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N Staiano

6

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C Pedone

7

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M Bolognesi

8

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V Pavone

The ornithodorin-thrombin crystal structure, a key to the TAP enigma?

9

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publication date

January 1999

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published in

Protein Science

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volume

8

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issue

1

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page(s)

91-5

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cites work

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

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The structure of a complex of recombinant hirudin and human alpha-thrombin

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Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

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Refined structure of the hirudin-thrombin complex

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

20 March 2017

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On the size of the active site in proteases. I. Papain

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex

20 March 2017

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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin

29 September 2017

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Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects

29 September 2017

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A player of many parts: the spotlight falls on thrombin's structure.

29 September 2017

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Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

29 September 2017

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The development of hirudin as an antithrombotic drug

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Thrombin active-site regions

29 September 2017

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Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

29 September 2017

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Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis

29 September 2017

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Molecular mechanisms of thrombin function

29 September 2017

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Isolation, sequence analysis, and cloning of haemadin. An anticoagulant peptide from the Indian leech

2 June 2018

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Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors

27 November 2018

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12 December 2020

Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis

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12 December 2020

The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution

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12 December 2020

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

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12 December 2020