Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding (Q27618361)

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English	Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding	scientific article

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scholarly article

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Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding (English)

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crystal structure

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object named as

W Xu

3

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author name string

H E Xu

1

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M A Rould

2

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J A Epstein

4

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R L Maas

5

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C O Pabo

6

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publication date

15 May 1999

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Genes & Development

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13

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10

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1263-75

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Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility

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20 March 2017

Identification of functional domains and evolution of Tc1-like transposable elements

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20 March 2017

A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex

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Co-crystal structure of TBP recognizing the minor groove of a TATA element

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20 March 2017

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20 March 2017

Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions

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20 March 2017

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

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20 March 2017

Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations

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20 March 2017

Solution structure of the ets domain of Fli-1 when bound to DNA

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20 March 2017

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

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20 March 2017

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions

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20 March 2017

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

The CCP4 suite: programs for protein crystallography

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

PAX6 mutations reviewed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

PAX6 missense mutation in isolated foveal hypoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

20 March 2017

The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

7 April 2017

Pax-6, a murine paired box gene, is expressed in the developing CNS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

7 April 2017

Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Pax genes and organogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Pax genes and their roles in cell differentiation and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Cooperative interactions between paired domain and homeodomain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Lens development and crystallin gene expression: many roles for Pax-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Pax3 modulates expression of the c-Met receptor during limb muscle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Multiple functions for Pax6 in mouse eye and nasal development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Evolution and role of Pax genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Mobile Minos elements from Drosophila hydei encode a two-exon transposase with similarity to the paired DNA-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Mammalian Pax genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

The role of Pax-6 in eye and nasal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Identification of DNA recognition sequences for the Pax3 paired domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Sequence-specific recognition of double helical nucleic acids by proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

29 September 2017

Chromosomal translocations involving paired box transcription factors in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Eye development: governed by a dictator or a junta?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Functional analysis of paired box missense mutations in the PAX6 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Role of Olf-1 and Pax-6 transcription factors in neurodevelopment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Pax-QNR/Pax-6, a paired- and homeobox-containing protein, recognizes Ets binding sites and can alter the transactivating properties of Ets transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Dissection of the Drosophila paired protein: functional requirements for conserved motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

2 June 2018

Mutational analysis of PAX6: 16 novel mutations including 5 missense mutations with a mild aniridia phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

27 November 2018

Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

27 November 2018

Roles of Pax-6 in murine diencephalic development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

27 November 2018

In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

27 November 2018

Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316729

27 November 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pax genes--paired feet in three camps

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The paired-domain regulates DNA binding by the homeodomain within the intact Pax-3 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C-terminal subdomain makes an important contribution to the DNA binding activity of the Pax-3 paired domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modular organization of Pax/homeodomain proteins in transcriptional regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten novel mutations found in Aniridia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Missense mutations in the PAX6 gene in aniridia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10346815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.13.10.1263

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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