Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis (Q27618672)

2

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C Pinko

3

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R E Showalter

4

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C V Parast

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A Tempczyk-Russell

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M R Gehring

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B Mroczkowski

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C C Kan

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J E Villafranca

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K Appelt

Differentiation of endothelium.

11

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language of work or name

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15 March 1999

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published in

Structure

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volume

7

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issue

3

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page(s)

319-30

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cites work

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Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate

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Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways

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Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

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Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

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Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase

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Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions

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Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation

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Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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7 January 2021

Active and inactive protein kinases: structural basis for regulation

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis

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Domain movements in protein kinases

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

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Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

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Identifiers

DOI

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Fatcat ID

release_gxybg3osvfg6plpsl3jefijorm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gxybg3osvfg6plpsl3jefijorm

24 November 2022