The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamase (Q27620652)

1

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J Blázquez

2

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G S Weston

3

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M I Morosini

4

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F Baquero

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B K Shoichet

Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design

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language of work or name

1 reference

November 1999

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published in

Protein Science

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volume

8

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issue

11

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page(s)

2330-7

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cites work

1 reference

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Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis

20 March 2017

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Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog

20 March 2017

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Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases

20 March 2017

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A functional classification scheme for beta-lactamases and its correlation with molecular structure

20 March 2017

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Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis

20 March 2017

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Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

20 March 2017

1 reference

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases

20 March 2017

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Mechanism of suppression of piperacillin resistance in enterobacteria by tazobactam

29 September 2017

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Penicillin-binding proteins and induction of AmpC beta-lactamase

29 September 2017

1 reference

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A plasmid-mediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg

29 September 2017

1 reference

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Molecular basis of beta-lactamase induction in bacteria

29 September 2017

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Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase

29 September 2017

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Inactivation of antibiotics and the dissemination of resistance genes

29 September 2017

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Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants

29 September 2017

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Protein-protein recognition via side-chain interactions

29 September 2017

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Beta-lactamase inhibitors and reversal of antibiotic resistance

29 September 2017

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beta-Lactamases of gram-negative bacteria: new challenges for new drugs

29 September 2017

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The crisis in antibiotic resistance

29 September 2017

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Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu

29 September 2017

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Transcriptional regulation of Escherichia coli K-12 major outer membrane protein 1b

29 September 2017

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The inhibition of class C beta-lactamases by boronic acids

29 September 2017

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Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

2 June 2018

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An extended-spectrum AmpC-type beta-lactamase obtained by in vitro antibiotic selection.

27 November 2018

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The evolution of beta-lactamases.

27 November 2018

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Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria.

27 November 2018

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The roles of residues Tyr150, Glu272, and His314 in class C beta-lactamases

27 November 2018

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The role of tyrosine 150 in catalysis of beta-lactam hydrolysis by AmpC beta-lactamase from Escherichia coli investigated by site-directed mutagenesis.

27 November 2018

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Molecular evolution of a class C beta-lactamase extending its substrate specificity

27 November 2018

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The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12.

27 November 2018

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Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/10595535