Site-directed ligand discovery (Q27626501)

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A C Braisted

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D R Raphael

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M Randal

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R M Stroud

5

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E M Gordon

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J A Wells

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

15 August 2000

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published in

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volume

97

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issue

17

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page(s)

9367-72

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cites work

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Structure-based design of inhibitors specific for bacterial thymidylate synthase

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The additivity of substrate fragments in enzyme-ligand binding

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

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Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases

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The CCP4 suite: programs for protein crystallography

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The finer things in X-ray diffraction data collection

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Structure-based discovery of inhibitors of thymidylate synthase

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The catalytic mechanism and structure of thymidylate synthase

20 March 2017

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Preferential heterodimer formation by isolated leucine zippers from fos and jun

20 March 2017

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Discovering high-affinity ligands for proteins: SAR by NMR

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Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors

7 April 2017

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29 September 2017

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Discovery of a herbicidal lead using polymer-bound activated esters in generating a combinatorial library of amides and esters

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Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

29 September 2017

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Thiol/disulfide exchange equilibria and disulfide bond stability

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Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa

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Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers

29 September 2017

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Inhibition of thymidylate synthase by pyridoxal phosphate

2 June 2018

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Ligand recognition by influenza virus. The binding of bivalent sialosides

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Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

2 June 2018

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Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

2 June 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.17.9367

Complete replacement set of amino acids at the C-terminus of thymidylate synthase: quantitative structure-activity relationship of mutants of an enzyme

21 January 2018

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12 December 2020

Direct spectrophotometric evidence for the oxidation of tetrahydrofolate during the enzymatic synthesis of thymidylate

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12 December 2020

Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate

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12 December 2020

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits

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12 December 2020

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

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12 December 2020

Kinetics of thymidylate synthase inhibition by disulfides

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12 December 2020

Deconstruction of GCN4/GCRE into a monomeric peptide-DNA complex

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12 December 2020

Identifiers

DOI

10.1073/PNAS.97.17.9367

1 reference

3308142

ADS bibcode

2000PNAS...97.9367E

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3308142

1 reference

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