Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor (Q27629282)

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R P Beckett

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A Brown

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G Catlin

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M Lobell

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S Palan

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W Thomas

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M Whittaker

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S Wood

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S Salama

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P J Baker

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H F Rodgers

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V Barynin

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D W Rice

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M G Hunter

Antimicrobial Agents and Chemotherapy

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language of work or name

English

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publication date

February 2001

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published in

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volume

45

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page(s)

563-70

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issue

2

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cites work

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Iron center, substrate recognition and mechanism of peptide deformylase

20 March 2017

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Solution structure of nickel-peptide deformylase

20 March 2017

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Structure of peptide deformylase and identification of the substrate binding site

20 March 2017

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Crystal structure of the Escherichia coli peptide deformylase

20 March 2017

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Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization

20 March 2017

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Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation

20 March 2017

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Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Automated refinement of protein models

20 March 2017

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The CCP4 suite: programs for protein crystallography

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Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

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Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents

20 March 2017

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Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene

29 September 2017

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Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

29 September 2017

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Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal

29 September 2017

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Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli

29 September 2017

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An Intramolecularly Quenched Fluorescent Tripeptide as a Fluorogenic Substrate of Angiotensin-I-Converting Enzyme and of Bacterial Dipeptidyl Carboxypeptidase

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Control of peptide deformylase activity by metal cations.

29 September 2017

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Formylation is not essential for initiation of protein synthesis in all eubacteria.

2 June 2018

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Design and Synthesis of Substrate Analogue Inhibitors of Peptide Deformylase†

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A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases

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Processing of X-ray diffraction data collected in oscillation mode

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A highly sensitive fluorometric assay for "enkephalinase," a neutral metalloendopeptidase that releases tyrosine-glycine-glycine from enkephalins

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Matrix metalloproteinases degrade myelin basic protein

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Oxygen-mediated inactivation of peptide deformylase

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H-phosphonate derivatives as novel peptide deformylase inhibitors

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12 December 2020

10.1128/AAC.45.2.563-570.2001

Identifiers

DOI

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release_yr2hqwlf4bcytbxkayoywalelq

2894242

Fatcat ID

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2894242

1 reference

1 reference

1 reference