Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment (Q27629324)

4

object named as

R Lührmann

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author name string

I Vidovic

1

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S Nottrott

2

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K Hartmuth

3

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R Ficner

Methods used in the structure determination of bovine mitochondrial F1 ATPase

5

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language of work or name

English

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publication date

December 2000

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published in

Molecular Cell

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volume

6

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issue

6

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page(s)

1331-42

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cites work

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PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle

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Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo

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Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing

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Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

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Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function.

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Fibrillarin binds directly and specifically to U16 box C/D snoRNA.

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A major family of motifs involving G.A mismatches in ribosomal RNA.

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Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.

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U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

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The detailed structure of tandem G.A mismatched base-pair motifs in RNA duplexes is context dependent

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Mutational analysis of Saccharomyces cerevisiae U4 small nuclear RNA identifies functionally important domains

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Electron-density map interpretation

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A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme?

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The structure and function of proteins involved in mammalian pre-mRNA splicing

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Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

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Local folding coupled to RNA binding in the yeast ribosomal protein L30

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A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex

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Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA

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Localization of a base-paired interaction between small nuclear RNAs U4 and U6 in intact U4/U6 ribonucleoprotein particles by psoralen cross-linking

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Mechanical devices of the spliceosome: motors, clocks, springs, and things

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Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins

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RNA recognition by a bent alpha-helix regulates transcriptional antitermination in phage lambda

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Costabilization of peptide and RNA structure in an HIV Rev peptide-RRE complex

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Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns

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Automated MAD and MIR structure solution

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Roles of U4 and U6 snRNAs in the assembly of splicing complexes.

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Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution

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A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP

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Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae

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Reconstitution of functional mammalian U4 small nuclear ribonucleoprotein: Sm protein binding is not essential for splicing in vitro

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The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNA

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Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex

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7 January 2021

U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction

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Site-specific crosslinking of mammalian U11 and u6atac to the 5' splice site of an AT-AC intron

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