Structural mechanism for statin inhibition of HMG-CoA reductase (Q27631717)

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English	Structural mechanism for statin inhibition of HMG-CoA reductase	scientific article

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scholarly article

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title

Structural mechanism for statin inhibition of HMG-CoA reductase (English)

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author

Johann Deisenhofer

series ordinal

2

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author name string

E S Istvan

series ordinal

1

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language of work or name

English

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publication date

11 May 2001

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published in

Science

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volume

292

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page(s)

1160-4

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issue

5519

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cites work

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

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Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase

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The structure of the catalytic portion of human HMG-CoA reductase

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Pharmacology of competitive inhibitors of HMG-CoA reductase.

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Low-density lipoprotein-independent effects of statins

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Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution

Structural mechanism for statin inhibition of HMG-CoA reductase (Q27631717)

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Structural mechanism for statin inhibition of HMG-CoA reductase (Q27631717)

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