Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA (Q27633013)

2

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E A Guenther

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V V Krishnan

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S Broyde

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K W Turteltaub

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M Cosman

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

17 July 2001

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published in

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volume

98

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issue

15

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page(s)

8507-12

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cites work

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Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus.

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Solution conformation of the (-)-trans-anti-benzo[c]phenanthrene-dA ([BPh]dA) adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrenyl ring to the 3'-side of the adduct site and comparison with the (+)-trans

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The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

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Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction

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Mutation and repair induced by the carcinogen 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in the dihydrofolate reductase gene of Chinese hamster ovary cells and conformational modeling of the dG-C8-PhIP adduct in DNA.

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DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats

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Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine.

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Solution structure of the aminofluorene [AF]-intercalated conformer of the syn-[AF]-C8-dG adduct opposite dC in a DNA duplex.

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Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex.

21 January 2018

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Solution structure of the aminofluorene [AF]-external conformer of the anti-[AF]-C8-dG adduct opposite dC in a DNA duplex.

21 January 2018

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2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk

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A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

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The role of DNA adducts in chemical carcinogenesis

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Reaction of the N2-acetoxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) with 2'-deoxyguanosine and DNA. Synthesis and identification of N2-(2'-deoxyguanosin-8-yl)-PhIP

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Identification of N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

21 January 2018

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Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA

21 January 2018

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Mutagenesis of the N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine DNA adduct in mammalian cells. Sequence context effects

21 January 2018

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Structural characterization of an N-acetyl-2-aminofluorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics

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Nuclear magnetic resonance solution structures of covalent aromatic amine-DNA adducts and their mutagenic relevance

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Prediction of DNA structure from sequence: a build-up technique

21 January 2018

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Structural Alignments of (+)- and (-)-trans-anti-Benzo[a]pyrene-dG Adducts Positioned at a DNA Replication Fork Junction

21 January 2018

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Structural characterization of two interchangeable conformations of a 2-aminofluorene-modified DNA oligomer by NMR and energy minimization

21 January 2018

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NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl

21 January 2018

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Dietary heterocyclic amines and the risk of lung cancer among Missouri women

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/11438709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11438709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11438709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.151251898

1 reference

release_meaazju3mjdt7mqqxaryfabjne

0 references

0 references

3679316

1 reference

1 reference

3679316

PubMed publication ID

11438709

1 reference