Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry (Q27638972)

5 July 2017

title

Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry (English)

1 reference

5 July 2017

main subject

antibiotic resistance

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Albert M Berghuis

2

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author name string

Desiree H Fong

series ordinal

1

1 reference

5 July 2017

language of work or name

English

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publication date

1 May 2002

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5 July 2017

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5 July 2017

volume

21

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5 July 2017

issue

10

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5 July 2017

page(s)

2323-2331

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Structural mechanisms of QacR induction and multidrug recognition

5 July 2017

cites work

1 reference

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Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase

20 March 2017

1 reference

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Aminoglycoside binding displaces a divalent metal ion in a tRNA-neomycin B complex

20 March 2017

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Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)

20 March 2017

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

20 March 2017

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Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold

20 March 2017

1 reference

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Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

20 March 2017

1 reference

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The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity

20 March 2017

1 reference

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Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase

20 March 2017

1 reference

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Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network

20 March 2017

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Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

20 March 2017

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The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

20 March 2017

1 reference

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Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase

20 March 2017

1 reference

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Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance

20 March 2017

1 reference

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Aminoglycoside phosphotransferases: proteins, structure, and mechanism

20 March 2017

1 reference

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Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Interaction of antibiotics with functional sites in 16S ribosomal RNA

20 March 2017

1 reference

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7 April 2017

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Molecular mechanisms that confer antibacterial drug resistance

29 September 2017

1 reference

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Changing patterns of infectious disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

29 September 2017

Macromolecular mimicry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Aminoglycoside antibiotics. Structures, functions, and resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Aminoglycosides: activity and resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Structural origins of gentamicin antibiotic action

29 September 2017

1 reference

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Genesis of methicillin-resistant Staphylococcus aureus (MRSA), how treatment of MRSA infections has selected for vancomycin-resistant Enterococcus faecium, and the importance of antibiotic management and infection control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

RNA surfaces as functional mimetics of proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Imprinting through molecular mimicry. Protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

29 September 2017

1 reference

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Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

The crystal structure of kanamycin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126009

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

19 June 2018

1 reference

12 December 2020

Aminoglycoside antibiotics bound to aminoglycoside-detoxifying enzymes and RNA adopt similar conformations

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Biologically important conformations of aminoglycoside antibiotics bound to an aminoglycoside 3'-phosphotransferase as determined by transferred nuclear Overhauser effect spectroscopy

1 reference

12 December 2020

Binding of neomycin-class aminoglycoside antibiotics to the A-site of 16 S rRNA

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/21.10.2323

1 reference

5 July 2017

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5 July 2017

1 reference