Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity (Q27641774)

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Stephen J. O'Keefe

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object named as

Stephen J O'Keefe

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author name string

Catherine E Fitzgerald

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Sangita B Patel

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Joseph W Becker

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Patricia M Cameron

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Dennis Zaller

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Vasilis Bill Pikounis

Nature structural biology

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publication date

September 2003

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published in

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volume

10

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issue

9

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page(s)

764-9

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cites work

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How MAP kinases are regulated

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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Osmotic regulation of cytokine synthesis in vitro

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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Structural basis of inhibitor selectivity in MAP kinases

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

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p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

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Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

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Peptide-plane flipping in proteins

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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

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Processing of X-ray diffraction data collected in oscillation mode

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Crystal structure of p38 mitogen-activated protein kinase

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Improved methods for building protein models in electron density maps and the location of errors in these models

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PROCHECK: a program to check the stereochemical quality of protein structures

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Multiple intracellular MAP kinase signaling cascades

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Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

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SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors

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Molecular basis for p38 protein kinase inhibitor specificity

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Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

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Conformational interconversions in peptide beta-turns: analysis of turns in proteins and computational estimates of barriers

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Signal transduction through MAP kinase cascades

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inferred from DOI database lookup

7 January 2021

based on heuristic

Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip

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