Coupling of folding and binding in the PTB domain of the signaling protein Shc (Q27641793)

1

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Lei Zeng

2

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Kelley S Yan

3

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Ming-Ming Zhou

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

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publication date

August 2003

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published in

Structure

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volume

11

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issue

8

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page(s)

905-13

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cites work

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7 January 2021

The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

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7 January 2021

Multidimensional heteronuclear nuclear magnetic resonance of proteins

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Protein backbone angle restraints from searching a database for chemical shift and sequence homology

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

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Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

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7 January 2021

Intrinsically disordered protein

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7 January 2021

Coupling of folding and binding for unstructured proteins

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7 January 2021

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

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7 January 2021

Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner

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7 January 2021

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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7 January 2021

Crystal structure of a beta-catenin/Tcf complex

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7 January 2021

Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone

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7 January 2021

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

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7 January 2021

NMR View: A computer program for the visualization and analysis of NMR data

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An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

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7 January 2021

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

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7 January 2021

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

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7 January 2021

Folding and binding cascades: dynamic landscapes and population shifts

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7 January 2021

Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors

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7 January 2021

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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7 January 2021

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

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7 January 2021

A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments.

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7 January 2021

Folding funnels and binding mechanisms

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7 January 2021

Ambiguous NOEs and automated NOE assignment

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7 January 2021

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

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7 January 2021

Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

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7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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7 January 2021

Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

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7 January 2021

Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression.

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7 January 2021

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes

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7 January 2021

Folding and binding cascades: shifts in energy landscapes

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7 January 2021

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

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7 January 2021

A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

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7 January 2021

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

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7 January 2021

Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc

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7 January 2021

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

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7 January 2021

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

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7 January 2021

Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb

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7 January 2021