Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV (Q27641796)

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Bernd Löffler

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Martine Stihle

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Walter Huber

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Armin Ruf

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Michael Hennig

Two highly conserved glutamic acid residues in the predicted β propeller domain of dipeptidyl peptidase IV are required for its enzyme activity

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language of work or name

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August 2003

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published in

Structure

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volume

11

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issue

8

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page(s)

947-59

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cites work

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7 January 2021

Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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A model of the active site of dipeptidyl peptidase IV predicted by comparative molecular field analysis and molecular modelling simulations

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A new mechanism in serine proteases catalysis exhibited by dipeptidyl peptidase IV (DP IV)--Results of PM3 semiempirical thermodynamic studies supported by experimental results

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7 January 2021

Refined crystal structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 A resolution

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Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors

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Proline specific peptidases

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Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris

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7 January 2021

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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Binding of adenosine deaminase to the lymphocyte surface via CD26

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Tissue sulfhydryl groups

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The conformation around the peptide bond between the P1- and P2-positions is important for catalytic activity of some proline-specific proteases

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Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

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Beta propellers: structural rigidity and functional diversity

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The anatomy of a bifunctional enzyme: structural basis for reduction of oxygen to water and synthesis of nitric oxide by cytochrome cd1

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7 January 2021

Prolyl Oligopeptidase

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7 January 2021

Catalysis of serine oligopeptidases is controlled by a gating filter mechanism

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Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue

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Expression of the rat CD26 antigen (dipeptidyl peptidase IV) on subpopulations of rat lymphocytes

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Dipeptidyl peptidase (DPP) IV in rat organs. Comparison of immunohistochemistry and activity histochemistry

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Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs

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Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

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A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide

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7 January 2021

NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV

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Dipeptidyl-peptidase IV from rat liver.

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CD26/dipeptidyl peptidase IV does not work as an adenosine deaminase-binding protein in rat cells

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Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence

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Novel sequences propel familiar folds

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma

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Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site

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7 January 2021

Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence

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Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

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Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface

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Efficient anisotropic refinement of macromolecular structures using FFT

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Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis

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7 January 2021

Good or evil: CD26 and HIV infection

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The alpha/beta hydrolase fold

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How to measure and predict the molar absorption coefficient of a protein

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7 January 2021

Protein folds propelled by diversity

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Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix.

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7 January 2021

Unusual secondary specificity of prolyl oligopeptidase and the different reactivities of its two forms toward charged substrates

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7 January 2021

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study

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7 January 2021

Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV?

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7 January 2021

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

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7 January 2021

On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain

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7 January 2021

The evolution of proteinase substrates with special reference to dipeptidylpeptidase IV.

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7 January 2021

Phosphoribosyl anthranilate isomerase from Thermotoga maritima is an extremely stable and active homodimer.

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7 January 2021

Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker

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7 January 2021

Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima

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7 January 2021

1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

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7 January 2021

Dipeptidyl-peptidase IV/CD26 on T cells: analysis of an alternative T-cell activation pathway

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7 January 2021