Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair (Q27641994)

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English	Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair	scientific article

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Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair (English)

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Erhard Hohenester

6

object named as

Erhard Hohenester

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5

object named as

Takako Sasaki

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author name string

Harald Wizemann

1

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Jörg H O Garbe

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Martin V K Friedrich

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Rupert Timpl

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language of work or name

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publication date

19 September 2003

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Journal of Molecular Biology

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332

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3

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635-42

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Supramolecular assembly of basement membranes

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Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins

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Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila.

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