Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases (Q27642040)

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11 September 2022

Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases (English)

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28 November 2023

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28 November 2023

4

T L Blundell

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author name string

B. Veerapandian

1

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11 September 2022

J. B. Cooper

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11 September 2022

A. Sali

3

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11 September 2022

T. L. Blundell

4

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11 September 2022

R. L. Rosati

5

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B. W. Dominy

6

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11 September 2022

D. B. Damon

7

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11 September 2022

D. J. Hoover

8

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11 September 2022

language of work or name

English

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National Center for Biotechnology Information

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full work available at URL

11 September 2022

publication date

March 1992

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https://europepmc.org/articles/PMC2142209

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11 September 2022

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11 September 2022

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open access

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28 November 2023

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28 November 2023

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28 November 2023

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1

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issue

3

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page(s)

322-8

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cites work

The active site of aspartic proteinases

1 reference

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Structure and refinement of penicillopepsin at 1.8 Å resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

X-ray studies of aspartic proteinase-statine inhibitor complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

The Protein Data Bank: a computer-based archival file for macromolecular structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Pepstatin, a new pepsin inhibitor produced by Actinomycetes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

The structure and function of the aspartic proteinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Electronic distributions within protein phenylalanine aromatic rings are reflected by the three-dimensional oxygen atom environments

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Pepsin-catalysed addition of water to a ketomethylene peptide isostere: observation of the tetrahedral species by 13C-nuclear-magnetic-resonance spectroscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Fluoro ketone containing peptides as inhibitors of human renin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Protein engineering of chymosin; modification of the optimum pH of enzyme catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5-A resolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Structure of ethanol-inhibited porcine pepsin at 2-A resolution and binding of the methyl ester of phenylalanyl-diiodotyrosine to the enzyme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

A systematic series of synthetic chromophoric substrates for aspartic proteinases

2 June 2018

1 reference

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Fluoro ketone inhibitors of hydrolytic enzymes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

Improved Fourier coefficients for maps using phases from partial structures with errors

2 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRO.5560010303

Crystal structure of a retroviral protease proves relationship to aspartic protease family

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142209

An x-ray crystallographic study of the rennin-like enzyme of Endothia parasitica

27 November 2018

1 reference

12 December 2020

Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin

1 reference

12 December 2020

The mechanism of action of aspartic proteases involves 'push-pull' catalysis

1 reference

12 December 2020

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues

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12 December 2020

Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors

1 reference

12 December 2020

Structure of crystalline alpha-chymotrypsin. IV. The structure of indoleacryloyl-alpha-chyotrypsin and its relevance to the hydrolytic mechanism of the enzyme

1 reference

12 December 2020

A graphics model building and refinement system for macromolecules

23

1 reference

https://api.crossref.org/works/10.1002/PRO.5560010303

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

28 November 2023

24

1 reference

https://api.crossref.org/works/10.1002/PRO.5560010303

X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution

28 November 2023

43

1 reference

https://api.crossref.org/works/10.1002/PRO.5560010303

28 November 2023

Identifiers

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PMC publication ID

2142209

0 references