Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor (Q27642840)

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16 November 2019

title

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor (English)

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16 November 2019

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4

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16 November 2019

Stevan R Hubbard

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16 November 2019

author name string

Junjie Hu

1

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16 November 2019

Jun Liu

2

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16 November 2019

Rodolfo Ghirlando

3

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16 November 2019

publication date

1 December 2003

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16 November 2019

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16 November 2019

volume

12

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16 November 2019

page(s)

1379-1389

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16 November 2019

issue

6

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Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling

16 November 2019

cites work

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7 January 2021

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

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Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insul

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7 January 2021

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

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7 January 2021

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

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7 January 2021

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

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7 January 2021

Determination of macromolecular structures from anomalous diffraction of synchrotron radiation

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7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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7 January 2021

Protein tyrosine kinase structure and function

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Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

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7 January 2021

Modular peptide recognition domains in eukaryotic signaling

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7 January 2021

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

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7 January 2021

The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport

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7 January 2021

Identification of the APS protein as a novel insulin receptor substrate

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7 January 2021

AMoRe: an automated package for molecular replacement

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7 January 2021

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

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7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

Mechanism-based design of a protein kinase inhibitor

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7 January 2021

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

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7 January 2021

SH2-B and APS are multimeric adapters that augment TrkA signaling

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7 January 2021

Identification and characterization of novel substrates of Trk receptors in developing neurons

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7 January 2021

Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

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7 January 2021

PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor

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7 January 2021

Insulin signaling pathways in time and space.

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7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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7 January 2021

Interaction of the Low-Affinity Receptor CD23/FcεRII Lectin Domain with the Fcε3−4 Fragment of Human Immunoglobulin E†

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7 January 2021

Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity

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7 January 2021

Characterization of Lnk. An adaptor protein expressed in lymphocytes

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7 January 2021

Maximum-likelihood density modification

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7 January 2021

Automated MAD and MIR structure solution

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7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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7 January 2021

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

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7 January 2021

The IRS-signalling system: a network of docking proteins that mediate insulin action

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7 January 2021

The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit

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7 January 2021

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

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7 January 2021

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Identifiers

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16 November 2019

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24 November 2022

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