Crystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA Polymerase (Q27643650)

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Amanda B Wass

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David W Gohara

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Harsh B Pathak

4

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Jamie J Arnold

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David J Filman

6

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James M Hogle

NMR structure of the viral peptide linked to the genome (VPg) of poliovirus

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language of work or name

1 reference

April 2007

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published in

Journal of Virology

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volume

81

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page(s)

3583-96

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issue

7

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cites work

1 reference

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The structure of a protein primer-polymerase complex in the initiation of genome replication

20 March 2017

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

20 March 2017

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Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase

20 March 2017

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Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg

20 March 2017

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20 March 2017

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Refined X-ray crystallographic structure of the poliovirus 3C gene product

20 March 2017

1 reference

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Structure of the RNA-dependent RNA polymerase of poliovirus

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Shape complementarity at protein/protein interfaces

20 March 2017

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Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B

20 March 2017

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Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs

20 March 2017

1 reference

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Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase

29 September 2017

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Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase

29 September 2017

1 reference

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Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer

29 September 2017

1 reference

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Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase

29 September 2017

1 reference

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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

29 September 2017

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The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein

29 September 2017

1 reference

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A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

29 September 2017

1 reference

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Active site tightness and substrate fit in DNA replication

29 September 2017

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29 September 2017

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Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro).

29 September 2017

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Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: purification and enzymatic analysis of the RNA-dependent RNA polymerase 3D(pol).

29 September 2017

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Oligomeric structures of poliovirus polymerase are important for function

29 September 2017

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The specificity loop of T7 RNA polymerase interacts first with the promoter and then with the elongating transcript, suggesting a mechanism for promoter clearance

29 September 2017

1 reference

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Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation

29 September 2017

1 reference

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Modulation of the RNA binding and protein processing activities of poliovirus polypeptide 3CD by the viral RNA polymerase domain

29 September 2017

1 reference

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Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase

29 September 2017

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Protein-primed RNA synthesis by purified poliovirus RNA polymerase

29 September 2017

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Mutation of lysine residues in the nucleotide binding segments of the poliovirus RNA-dependent RNA polymerase.

29 September 2017

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Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis

29 September 2017

1 reference

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Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA.

29 September 2017

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Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication.

29 September 2017

1 reference

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Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage

29 September 2017

1 reference

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Purification and properties of poliovirus RNA polymerase expressed in Escherichia coli.

29 September 2017

1 reference

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Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Factors required for the Uridylylation of the foot-and-mouth disease virus 3B1, 3B2, and 3B3 peptides by the RNA-dependent RNA polymerase (3Dpol) in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Enzymatic activity of poliovirus RNA polymerase synthesized in Escherichia coli from viral cDNA.

2 June 2018

1 reference

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Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

The unusual catalytic triad of poliovirus protease 3C.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866080

Visualization and functional analysis of RNA-dependent RNA polymerase lattices

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17251299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17251299