Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity (Q27644014)

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Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

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English	Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity	scientific article	Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

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scholarly article

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity (English)

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5

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Matthew Meyerson

6

object named as

Matthew Meyerson

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2

object named as

Titus J Boggon

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author name string

Cai-Hong Yun

1

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Yiqun Li

3

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Michele S Woo

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Michael J Eck

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language of work or name

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publication date

March 2007

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11

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217-27

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3

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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20 March 2017

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

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20 March 2017

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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Halogen bonds in biological molecules

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20 March 2017

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20 March 2017

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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20 March 2017

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

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The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

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20 March 2017

Crystal structure of the Src family tyrosine kinase Hck

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20 March 2017

Three-dimensional structure of the tyrosine kinase c-Src

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20 March 2017

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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20 March 2017

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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20 March 2017

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20 March 2017

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20 March 2017

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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20 March 2017

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20 March 2017

Untangling the ErbB signalling network

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20 March 2017

Automated protein model building combined with iterative structure refinement

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20 March 2017

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20 March 2017

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Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

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7 April 2017

Crystal structure of cyclin-dependent kinase 2

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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib

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29 September 2017

Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy

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29 September 2017

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

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Epidermal growth factor receptor mutations in patients with non-small cell lung cancer

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Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

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29 September 2017

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

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Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.

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Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.

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Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474.

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AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity

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Imatinib: the first 3 years

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Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

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Processing of X-ray diffraction data collected in oscillation mode

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Identifiers

10.1016/J.CCR.2006.12.017

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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