Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia (Q27644461)

2

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Kieran F Geoghegan

3

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Matthew C Griffor

4

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Julie L Hawkins

5

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Timothy A Subashi

6

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Alison H Varghese

7

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Mark J Ammirati

8

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Jeffrey S Culp

9

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Lise R Hoth

10

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Mahmoud N Mansour

11

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Katherine M McGrath

12

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Andrew P Seddon

13

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Shirish Shenolikar

14

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Kim J Stutzman-Engwall

15

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Laurie C Warren

16

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Donghui Xia

17

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Xiayang Qiu

Nature Structural & Molecular Biology

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publication date

May 2007

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published in

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volume

14

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page(s)

413-9

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issue

5

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cites work

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

21 April 2017

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 April 2017

1 reference

The proprotein convertases and their implication in sterol and/or lipid metabolism

21 April 2017

1 reference

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

21 April 2017

1 reference

2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor

21 April 2017

1 reference

Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus

21 April 2017

1 reference

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

21 April 2017

1 reference

Functional characterization of Narc 1, a novel proteinase related to proteinase K

21 April 2017

1 reference

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution

21 April 2017

1 reference

Structure of the LDL receptor extracellular domain at endosomal pH

21 April 2017

1 reference

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

21 April 2017

1 reference

Molecular biology of PCSK9: its role in LDL metabolism

21 April 2017

1 reference

Expression and localization of PCSK9 in rat hepatic cells

21 April 2017

1 reference

Regulation of transcription factor latency by receptor-activated proteolysis

21 April 2017

1 reference

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

21 April 2017

1 reference

Molecular medicine. The cholesterol quartet

21 April 2017

1 reference

Structure and physiologic function of the low-density lipoprotein receptor

31 March 2020

1 reference

Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia

31 March 2020

1 reference

PCSK9: a promising therapeutic target for dyslipidemias?

31 March 2020

1 reference

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

31 March 2020

1 reference

Biomedicine. Lowering LDL--not only how low, but how long?

31 March 2020

1 reference

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

31 March 2020

1 reference

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

31 March 2020

1 reference

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

31 March 2020

1 reference

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

31 March 2020

1 reference

Targeting proteases: successes, failures and future prospects

31 March 2020

1 reference

1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase

31 March 2020

1 reference

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

31 March 2020

1 reference

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors

31 March 2020

1 reference

Analysis of the proteolytic activity of a recombinant form of apolipoprotein(a).

31 March 2020

1 reference

The CCP4 suite: programs for protein crystallography

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB1235

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

913417

1035856633

0 references

Fatcat ID

release_52cm6tjtwffbfevkpq5uiolyzi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/52cm6tjtwffbfevkpq5uiolyzi

mapped directly with Wikidata item

24 November 2022

based on heuristic

913417

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference