Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects (Q27646616)

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English	Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects	scientific article

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1 January 2020

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects (English)

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1 January 2020

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Dirk Bornemeier

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Adam R Johnson

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1 January 2020

Alexander G Pavlovsky

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Daniel F Ortwine

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Faith Prior

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Chiu-Fai Man

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Craig A Banotai

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W Thomas Mueller

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Patrick McConnell

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Chunhong Yan

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Vijay Baragi

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1 January 2020

Charles Lesch

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W Howard Roark

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Michael Wilson

14

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1 January 2020

Kaushik Datta

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1 January 2020

Roberto Guzman

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1 January 2020

Hyo-Kyung Han

17

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1 January 2020

Richard D Dyer

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10 July 2007

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1 January 2020

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11

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Journal of Biological Chemistry

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1 January 2020

282

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27781-27791

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1 January 2020

Biochemical characterization of human collagenase-3

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

The multiple contributions of thyroid hormone to heat production

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21 January 2018

Metalloproteinases: their role in arthritis and potential as therapeutic targets

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Preclinical and clinical studies of MMP inhibitors in cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats

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21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

AMoRe: an automated package for molecular replacement

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21 January 2018

The Protein Data Bank

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21 January 2018

Refinement of macromolecular structures by the maximum-likelihood method

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21 January 2018

Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors

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21 January 2018

Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor

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21 January 2018

Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure

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21 January 2018

On the size of the active site in proteases. I. Papain

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21 January 2018

Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases

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21 January 2018

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition

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21 January 2018

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity

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21 January 2018

Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation

1 reference

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21 January 2018

Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis

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21 January 2018

Structural basis for the highly selective inhibition of MMP-13.

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https://api.crossref.org/works/10.1074%2FJBC.M703286200

21 January 2018

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice

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21 January 2018

The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis.

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21 January 2018

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10.1074/JBC.M703286200

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Europe PubMed Central

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1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17623656%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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