A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase. (Q27648381)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17884090%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase (English)

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7 January 2020

1

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7 January 2020

author name string

Tamara A Dailey

2

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7 January 2020

Teresa A Ross

3

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7 January 2020

Harry A Dailey

4

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7 January 2020

William N Lanzilotta

5

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language of work or name

English

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publication date

23 August 2007

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Journal of Molecular Biology

7 January 2020

published in

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volume

373

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7 January 2020

issue

4

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7 January 2020

page(s)

1006-1016

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Altered Orientation of Active Site Residues in Variants of Human Ferrochelatase. Evidence for a Hydrogen Bond Network Involved in Catalysis †

7 January 2020

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1 reference

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Substrate interactions with human ferrochelatase

20 March 2017

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Amino acid residues His183 and Glu264 in Bacillus subtilis ferrochelatase direct and facilitate the insertion of metal ion into protoporphyrin IX

20 March 2017

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Chelatases: distort to select?

20 March 2017

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Metal binding to Bacillus subtilis ferrochelatase and interaction between metal sites

20 March 2017

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Metal binding to Saccharomyces cerevisiae ferrochelatase

20 March 2017

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The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis

20 March 2017

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Structural and mechanistic basis of porphyrin metallation by ferrochelatase

20 March 2017

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Crystal structure of ferrochelatase: the terminal enzyme in heme biosynthesis

20 March 2017

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Occurrence, conformational features and amino acid propensities for the pi-helix

20 March 2017

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Heme is involved in microRNA processing

20 March 2017

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Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine leads to porphyrin substrate-bound variants

20 March 2017

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Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases

20 March 2017

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Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex

20 March 2017

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Mitoferrin is essential for erythroid iron assimilation

20 March 2017

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Probing the active site loop motif of murine ferrochelatase by random mutagenesis

20 March 2017

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Structure, function, and formation of biological iron-sulfur clusters

20 March 2017

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Direct measurement of metal ion chelation in the active site of human ferrochelatase

7 April 2017

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Iron uptake and metabolism in the new millennium.

29 September 2017

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29 September 2017

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Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases

29 September 2017

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Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes

29 September 2017

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Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects.

29 September 2017

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Crosstalk between metal ions in Bacillus subtilis ferrochelatase

29 September 2017

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29 September 2017

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Iron trafficking in the mitochondrion: novel pathways revealed by disease.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway

29 September 2017

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Production and characterization of erythropoietic protoporphyric heterodimeric ferrochelatases

29 September 2017

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Antibody-catalyzed porphyrin metallation.

2 June 2018

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The interaction of mitochondrial ferrochelatase with a range of porphyrin substrates

2 June 2018

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Metallation of the transition-state inhibitor N-methyl mesoporphyrin by ferrochelatase: implications for the catalytic reaction mechanism

2 June 2018

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Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by Resonance Raman spectroscopy

27 November 2018

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The importance of porphyrin distortions for the ferrochelatase reaction

27 November 2018

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Human ferrochelatase: characterization of substrate-iron binding and proton-abstracting residues

27 November 2018

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Human ferrochelatase: crystallization, characterization of the [2Fe-2S] cluster and determination that the enzyme is a homodimer

27 November 2018

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12 December 2020

Porphyrin interactions with wild-type and mutant mouse ferrochelatase

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12 December 2020

Studies on the biosynthesis of heme in vitro by avian erythrocytes

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12 December 2020

Formation of heme by broken-cell preparations of duck erythrocytes

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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Interaction of free porphyrins and metalloporphyrins with mouse ferrochelatase. A model for the active site of ferrochelatase

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Probing the active-site residues in Saccharomyces cerevisiae ferrochelatase by directed mutagenesis. In vivo and in vitro analyses

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12 December 2020

Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions

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12 December 2020

10.1016/J.JMB.2007.08.040

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