Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR (Q27649095)

7

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Giorgos Gouridis

object named as

Giorgos Gouridis

5

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author name string

Ioannis Gelis

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Dimitra Keramisanou

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Marina Koukaki

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Spyridoula Karamanou

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Charalampos G Kalodimos

Preprotein-controlled catalysis in the helicase motor of SecA

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language of work or name

English

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publication date

16 November 2007

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published in

Cell

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volume

131

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issue

4

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page(s)

756-69

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cites work

1 reference

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X-ray structure of a protein-conducting channel

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Structural determinants of SecB recognition by SecA in bacterial protein translocation

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Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

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Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

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The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA

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Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function

20 March 2017

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Selective photoaffinity labeling identifies the signal peptide binding domain on SecA

7 April 2017

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Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment

29 September 2017

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Different modes of SecY-SecA interactions revealed by site-directed in vivo photo-cross-linking

29 September 2017

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Visualization of transient encounter complexes in protein-protein association.

29 September 2017

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The surprising complexity of signal sequences

29 September 2017

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Detecting transient intermediates in macromolecular binding by paramagnetic NMR.

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Protein translocation across biological membranes

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Protein translocation by the Sec61/SecY channel

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Demonstration of a specific Escherichia coli SecY-signal peptide interaction

29 September 2017

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A large conformational change of the translocation ATPase SecA

29 September 2017

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SecB, one small chaperone in the complex milieu of the cell

29 September 2017

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The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation.

29 September 2017

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Binding of SecB to ribosome-bound polypeptides has the same characteristics as binding to full-length, denatured proteins

29 September 2017

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Two distinct ATP-binding domains are needed to promote protein export by Escherichia coli SecA ATPase

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Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer.

29 September 2017

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Identification of the preprotein binding domain of SecA.

2 June 2018

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The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins

2 June 2018

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Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel.

2 June 2018

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Disorder-order folding transitions underlie catalysis in the helicase motor of SecA

27 November 2018

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Selective SecA association with signal sequences in ribosome-bound nascent chains: a potential role for SecA in ribosome targeting to the bacterial membrane.

27 November 2018

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27 November 2018

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Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state

27 November 2018

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Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity

27 November 2018

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The hydrophobic region of signal peptides is involved in the interaction with membrane-bound SecA.

27 November 2018

1 reference

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Solution NMR of supramolecular complexes: providing new insights into function

27 November 2018

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12 December 2020

SecA interacts with secretory proteins by recognizing the positive charge at the amino terminus of the signal peptide in Escherichia coli

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12 December 2020

A molecular switch in SecA protein couples ATP hydrolysis to protein translocation

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12 December 2020

Signal peptide determinants of SecA binding and stimulation of ATPase activity

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12 December 2020

Tyr-326 plays a critical role in controlling SecA-preprotein interaction

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12 December 2020

Determination of a region in SecA that interacts with presecretory proteins in Escherichia coli

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12 December 2020

Co- and post-translational translocation through the protein-conducting channel: analogous mechanisms at work?

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12 December 2020

Quantitative dynamics and binding studies of the 20S proteasome by NMR

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12 December 2020

10.1016/J.CELL.2007.09.039

Identifiers

DOI

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2617135

2617135

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1 reference

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