Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex † (Q27649179)

1

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Michael R Jackson

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Eugene F DeRose

3

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Robert E London

Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+complex reveals a novel cofactor binding mode

5

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language of work or name

English

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publication date

25 December 2007

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published in

Biochemistry

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volume

46

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issue

51

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page(s)

14878-88

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cites work

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2 June 2018

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2 June 2018

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Calorimetric studies of ligand binding in R67 dihydrofolate reductase

27 November 2018

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Multiple ligand-binding modes in bacterial R67 dihydrofolate reductase

27 November 2018

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27 November 2018

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Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis

27 November 2018

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Transition state stabilization and substrate strain in enzyme catalysis: ab initio QM/MM modelling of the chorismate mutase reaction.

27 November 2018

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Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

27 November 2018

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NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743094

Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase

27 November 2018

1 reference

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Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743094

Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743094

Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743094

Interligand Overhauser effects in type II dihydrofolate reductase

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743094

Effects of single-tryptophan mutations on R67 dihydrofolate reductase.

27 November 2018

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Titration of histidine 62 in R67 dihydrofolate reductase is linked to a tetramer<-->two-dimer equilibrium.

27 November 2018

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Trimethoprim resistance determined by R factors

27 November 2018

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The dissociation constants of tetrahydrofolic acid

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Dissociation constants for dihydrofolic acid and dihydrobiopterin and implications for mechanistic models for dihydrofolate reductase

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Carbon-13 nuclear magnetic resonance study of protonation of methotrexate and aminopterin bound to dihydrofolate reductase

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Protonation of methotrexate bound to the catalytic site of dihydrofolate from Lactobacillus casei

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12 December 2020

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Identifiers

DOI

10.1021/BI701532R

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release_a6qjjxdqmzakrg336loir3alxa

Fatcat ID

0 references

1 reference

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PubMed publication ID

18052202

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