Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development (Q27649767)

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2 January 2020

title

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development (English)

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12

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2 January 2020

William Nigel Hunter

3

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2 January 2020

Francisco Gamarro

4

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2 January 2020

Lindsay Tulloch

10

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2 January 2020

Maria Paola Costi

13

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2 January 2020

author name string

Antonio Cavazzuti

1

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2 January 2020

Giuseppe Paglietti

2

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2 January 2020

Sandra Piras

5

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2 January 2020

Mario Loriga

6

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2 January 2020

Sergio Allecca

7

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2 January 2020

Paola Corona

8

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2 January 2020

Karen McLuskey

9

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2 January 2020

Federica Gibellini

11

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2 January 2020

language of work or name

English

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publication date

1 February 2008

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Proceedings of the National Academy of Sciences of the United States of America

2 January 2020

published in

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volume

105

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2 January 2020

issue

5

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2 January 2020

page(s)

1448-1453

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describes a project that uses

2 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Studies on transformation of Escherichia coli with plasmids

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Anticancer Antifolates: Current Status and Future Directions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Thymidylate synthase structure, function and implication in drug discovery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Mechanisms of resistance of malaria parasites to antifolates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Antimicrobial dihydrofolate reductase inhibitors--achievements and future options: review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-([4-(substituted 2-quinoxalinyloxy) phenyl] acetyl) glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Isobolographic analysis of interactions: an update on applications and utility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Cloning, expression and characterization of thymidylate synthase from Cryptococcus neoformans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

High-level expression of human thymidylate synthase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Destruction of Leishmania mexicana amazonensis amastigotes by leucine methyl ester: protection by other amino acid esters

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Purification and characterization of recombinant Pneumocystis carinii thymidylate synthase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Properties of a defined mutant of Escherichia coli thymidylate synthase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234164

Trypanosoma cruzi genome encodes a pteridine reductase 2 protein

19 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro eva

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

A model for the efficacy of combined inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704384105

Short-course of oral miltefosine for treatment of visceral leishmaniasis

21 January 2018

1 reference

12 December 2020

Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds

1 reference

12 December 2020

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

1 reference

12 December 2020

Quinoxaline chemistry. Part 11. 3-Phenyl-2 [phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl]benzoylglutamates. Synthesis and evaluation

1 reference

12 December 2020

Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0704384105

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245389%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

ADS bibcode

2008PNAS..105.1448C

0 references

1 reference

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2 January 2020

2 references