C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition (Q27649785)

1

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Pascale Tacnet-Delorme

2

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Virginie Garlatti

3

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Claudine Darnault

4

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Berhane Ghebrehiwet

5

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Gérard J Arlaud

7

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Philippe Frachet

Hide and seek: the secret identity of the phosphatidylserine receptor

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language of work or name

English

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publication date

15 February 2008

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published in

Journal of Immunology

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volume

180

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issue

4

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page(s)

2329-38

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cites work

1 reference

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The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

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The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity

20 March 2017

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Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals

20 March 2017

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The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties

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C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

20 March 2017

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Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

20 March 2017

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Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V

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20 March 2017

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Pulmonary surfactant protein D specifically binds to phosphatidylinositol

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

20 March 2017

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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

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The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells

29 September 2017

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CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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C1q, autoimmunity and apoptosis

29 September 2017

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Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells

29 September 2017

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Corpse clearance defines the meaning of cell death

29 September 2017

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A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo

29 September 2017

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Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages

29 September 2017

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29 September 2017

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C1q knock-out mice for the study of complement deficiency in autoimmune disease

29 September 2017

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Formation of supported planar bilayers by fusion of vesicles to supported phospholipid monolayers

29 September 2017

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Differential elution of Clq, Clr and Cls from human Cl bound to immune aggregates. Use in the rapid purification of Cl subcomponents

29 September 2017

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Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action

29 September 2017

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Localisation of the C1q binding site within C1q receptor/calreticulin

2 June 2018

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Complement protein C1q recognizes a conformationally modified form of the prion protein.

2 June 2018

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Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions

27 November 2018

1 reference

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Comparison of the properties of phospholipid surfaces formed on HPA and L1 biosensor chips for the binding of the coagulation factor VIII.

27 November 2018

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Complement facilitates early prion pathogenesis

27 November 2018

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Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2632962

Surface expression of phosphatidylserine on macrophages is required for phagocytosis of apoptotic thymocytes.

27 November 2018

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Genetic susceptibility to lupus nephritis.

27 November 2018

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Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines

27 November 2018

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Purification and characterization of C4-binding protein from human serum

27 November 2018

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12 December 2020

UV-B irradiated cell lines execute programmed cell death in various forms

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12 December 2020

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

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12 December 2020

Immunosuppressive effects of apoptotic cells

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12 December 2020

Treatment with annexin V increases immunogenicity of apoptotic human T-cells in Balb/c mice

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12 December 2020

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12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

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12 December 2020

Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma

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12 December 2020

The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells

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12 December 2020

Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey

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12 December 2020

Maturation of dendritic cells abrogates C1q production in vivo and in vitro

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12 December 2020

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells

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12 December 2020

Maturation-dependent expression of C1q binding proteins on the cell surface of human monocyte-derived dendritic cells

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12 December 2020

Reconstitution of the Complement Function in C1q-Deficient (C1qa-/-) Mice with Wild-Type Bone Marrow Cells

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12 December 2020

10.4049/JIMMUNOL.180.4.2329

Identifiers

DOI

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release_g3tszkglurb3hggtrpekkxgqfu

Fatcat ID

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1 reference

1 reference

PubMed publication ID

18250442

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