Structural and biochemical evidence for a boat-like transition state in beta-mannosidases (Q27650314)

12

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author name string

Louise E Tailford

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Wendy A Offen

2

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Nicola L Smith

3

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Carl Morland

5

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Julie Gratien

6

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Marie-Pierre Heck

7

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Robert V Stick

8

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Yves Blériot

9

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Andrea Vasella

10

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Harry J Gilbert

Mapping the conformational itinerary of beta-glycosidases by X-ray crystallography

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publication date

May 2008

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published in

Nature Chemical Biology

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volume

4

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issue

5

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page(s)

306-12

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cites work

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Glycosidase mechanisms

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4,6-O-benzylidene-directed beta-mannopyranosylation and alpha-glucopyranosylation: the 2-deoxy-2-fluoro and 3-deoxy-3-fluoro series of donors and the importance of the O2-C2-C3-O3 interaction

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Suppression of tumor growth and metastasis in Mgat5-deficient mice

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Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies

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Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms

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A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II.

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Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state

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Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: potent competitive inhibitors of mannosidases

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Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates

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Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A

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Synthesis of 5-amino-5-deoxy-d-mannopyranose and 1,5-di-deoxy-1,5-imino-d-mannitol, and inhibition of α- and β-d-mannosidases

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Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics

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Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors†,‡

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Transition-State Mimicry by Glycosidase Inhibitors: A Critical Kinetic Analysis

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Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases

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Mechanism, mutagenesis, and chemical rescue of a beta-mannosidase from cellulomonas fimi

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Common Inhibition of Both β-Glucosidases and β-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis

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Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases

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Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

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Thermodynamics of Inhibitor Binding to Mutant Forms of Glucoamylase from Aspergillus niger Determined by Isothermal Titration Calorimetry

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Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase

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Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.

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