Crystal structures ofMycobacterium tuberculosisS-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors (Q27652285)

1

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Gokulan Kuppan

2

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Nishant D Shetty

3

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Joshua L Owen

4

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James C Sacchettini

Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents

6

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language of work or name

1 reference

December 2008

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published in

Protein Science

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volume

17

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issue

12

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page(s)

2134-44

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cites work

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Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions

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Concanavalin A in a dimeric crystal form: revisiting structural accuracy and molecular flexibility

20 March 2017

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Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190

20 March 2017

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Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine

20 March 2017

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Comprehensive identification of conditionally essential genes in mycobacteria

20 March 2017

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Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme

20 March 2017

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Crystal structure of S-adenosylhomocysteine hydrolase from rat liver

20 March 2017

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Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

20 March 2017

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

20 March 2017

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Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Raster3D Version 2.0. A program for photorealistic molecular graphics

20 March 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

20 March 2017

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The finer things in X-ray diffraction data collection

20 March 2017

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20 March 2017

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

29 September 2017

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Remarks about protein structure precision

20 March 2017

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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

20 March 2017

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Solvent content of protein crystals

20 March 2017

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S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis

20 March 2017

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Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives

20 March 2017

1 reference

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The mechanism of action of S-adenosylhomocysteinase

20 March 2017

1 reference

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

20 March 2017

1 reference

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Rat liver S-adenosylhomocysteinase. Spectrophotometric study of coenzyme binding

20 March 2017

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A new and rapid colorimetric determination of acetylcholinesterase activity

20 March 2017

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Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

7 April 2017

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Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase

7 April 2017

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Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs--worldwide, 2000-2004.

29 September 2017

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responses of mycobacterium tuberculosis to growth in the mouse lung

29 September 2017

1 reference

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S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.

29 September 2017

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The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule

29 September 2017

1 reference

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Structure and function of S-adenosylhomocysteine hydrolase

29 September 2017

1 reference

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S-Adenosylmethionine and methylation

29 September 2017

1 reference

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Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization

29 September 2017

2 references

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29 September 2017

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Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells.

21 January 2018

1 reference

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S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Bayesian phylogenetic analysis reveals two-domain topology of S-adenosylhomocysteine hydrolase protein sequences

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

A colorimetric assay for S-adenosylhomocysteine hydrolase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Measurement errors and their consequences in protein crystallography

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2590921

ANTIMICROBIAL ACTIVITY OF 2-FLUOROADENOSINE AND 2-FLUOROADENINE

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18815415

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aristeromycin-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18815415

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18815415