Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38 (Q27652605)

2

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Hong Jiang

3

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Richard Graeff

4

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Hening Lin

5

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Hon Cheung Lee

6

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Quan Hao

Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38

7

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language of work or name

1 reference

20 October 2008

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published in

Chemistry and Biology

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volume

15

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issue

10

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page(s)

1068-78

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cites work

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo

20 March 2017

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Crystal structure of human CD38 extracellular domain

20 March 2017

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Structural basis for the activation of cholera toxin by human ARF6-GTP

20 March 2017

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The Sir2 family of protein deacetylases

20 March 2017

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Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity

20 March 2017

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20 March 2017

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Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.

7 April 2017

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Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).

29 September 2017

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DNA repair, genome stability, and aging

29 September 2017

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Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites

29 September 2017

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Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.

29 September 2017

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Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling

29 September 2017

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SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

29 September 2017

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Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers

29 September 2017

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Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice

29 September 2017

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Enzymatic functions and structures of CD38 and homologs.

29 September 2017

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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.

29 September 2017

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Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.

29 September 2017

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NAD hydrolysis: chemical and enzymatic mechanisms

29 September 2017

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Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.

29 September 2017

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Concerning the mechanism of the enzymatic and nonenzymatic hydrolysis of nicotinamide nucleotide coenzymes

29 September 2017

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Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin

29 September 2017

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Structure and enzymatic functions of human CD38.

2 June 2018

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Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases

2 June 2018

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CD38 is critical for social behaviour by regulating oxytocin secretion

2 June 2018

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Leaving group activation by aromatic stacking: an alternative to general acid catalysis

27 November 2018

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Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity

27 November 2018

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CD38 gene disruption inhibits the contraction induced by alpha-adrenoceptor stimulation in mouse aorta

27 November 2018

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Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption

27 November 2018

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Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase

27 November 2018

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CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion

27 November 2018

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Identification of the enzymatic active site of CD38 by site-directed mutagenesis

27 November 2018

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12 December 2020

Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Production and hydrolysis of cyclic ADP-ribose at the outer surface of human erythrocytes

1 reference

12 December 2020

ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP

1 reference

12 December 2020

Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase

1 reference

12 December 2020

The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries

1 reference

12 December 2020