Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD (Q27657225)

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English	Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD	scientific article

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6 February 2020

Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD (English)

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6 February 2020

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clinical chemistry

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6 February 2020

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6 February 2020

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Yongping Pan

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6 February 2020

Yvonne Eyobo

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6 February 2020

Irina Rodionova

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6 February 2020

Nian Huang

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6 February 2020

Oleg Kurnasov

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6 February 2020

Shijun Zhong

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6 February 2020

Hong Zhang

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6 February 2020

Andrei L Osterman

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1 August 2009

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6 February 2020

Chemistry and Biology

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6 February 2020

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6 February 2020

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6 February 2020

849-861

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6 February 2020

Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770502

20 March 2017

Kinetic and X-Ray Structural Evidence for Negative Cooperativity in Substrate Binding to Nicotinate Mononucleotide Adenylyltransferase (NMAT) from Bacillus anthracis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770502

20 March 2017

Structure of nicotinic acid mononucleotide adenylyltransferase fromBacillus anthracis

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20 March 2017

NAD kinases use substrate-assisted catalysis for specific recognition of NAD

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20 March 2017

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

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20 March 2017

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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20 March 2017

Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis

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20 March 2017

From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways

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20 March 2017

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD

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20 March 2017

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin

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20 March 2017

Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis

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20 March 2017

Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

The CCP4 suite: programs for protein crystallography

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20 March 2017

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

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20 March 2017

An approach to multi-copy search in molecular replacement

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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20 March 2017

Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis

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20 March 2017

Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli

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20 March 2017

Genes required for mycobacterial growth defined by high density mutagenesis

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20 March 2017

Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis

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20 March 2017

Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research

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7 April 2017

NAD(P) biosynthesis enzymes as potential targets for selective drug design

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29 September 2017

The NMN/NaMN adenylyltransferase (NMNAT) protein family.

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29 September 2017

Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs).

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29 September 2017

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Enzymology of mammalian NAD metabolism in health and disease

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29 September 2017

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29 September 2017

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

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29 September 2017

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29 September 2017

A subsystems-based approach to the identification of drug targets in bacterial pathogens.

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29 September 2017

NAD+ utilization in Pasteurellaceae: simplification of a complex pathway.

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29 September 2017

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Screening in a spirit haunted world

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29 September 2017

Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer

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29 September 2017

Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.

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Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa in its Apo and substrate-complexed forms reveals a fully open conformation

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Probing binding requirements of NAD kinase with modified substrate (NAD) analogues

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Processing of X-ray diffraction data collected in oscillation mode

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Identifiers

10.1016/J.CHEMBIOL.2009.07.006

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Europe PubMed Central

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