2.6 Å X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase, (Q27657290)

1

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Bingsen Zhou

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Nam Ho

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Yate-Ching Yuan

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Leila Su

5

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Shiou-Chuan Tsai

6

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Yun Yen

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2

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language of work or name

English

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publication date

24 November 2009

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published in

Biochemistry

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volume

48

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issue

46

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page(s)

11134-41

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cites work

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p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

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Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase

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Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

20 March 2017

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Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone.

20 March 2017

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S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

29 September 2017

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Di-iron-tyrosyl radical ribonucleotide reductases

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Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase

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A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases

29 September 2017

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Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

2 June 2018

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Role of a proximal NF-Y binding promoter element in S phase-specific expression of mouse ribonucleotide reductase R2 gene

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Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse

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Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

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