Active site remodeling switches HIV specificity of antiretroviral TRIMCyp (Q27657485)

1

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Flavia Marzetta

2

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Michael Lammers

3

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Laura M J Ylinen

4

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Sam J Wilson

6

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Greg J Towers

7

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Leo C James

Nature Structural & Molecular Biology

8

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publication date

October 2009

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published in

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volume

16

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page(s)

1036-42

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issue

10

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cites work

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Independent evolution of an antiviral TRIMCyp in rhesus macaques

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Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor

20 March 2017

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Structural insights into the catalytic mechanism of cyclophilin A

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Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

20 March 2017

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Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A

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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

22 April 2017

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

7 April 2017

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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

22 April 2017

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Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

7 April 2017

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

7 April 2017

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An efficient one-step site-directed and site-saturation mutagenesis protocol

22 April 2017

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Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

22 April 2017

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Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species

29 September 2017

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TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis

29 September 2017

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Cyclophilin A interacts with diverse lentiviral capsids

29 September 2017

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Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles

29 September 2017

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Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity

29 September 2017

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The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates

29 September 2017

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Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction

29 September 2017

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A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction

29 September 2017

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Influence of gag on human immunodeficiency virus type 1 species-specific tropism

29 September 2017

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A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3556581

A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).

29 September 2017

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Phylogenetic analysis of 49 newly derived HIV-1 group O strains: high viral diversity but no group M-like subtype structure.

29 September 2017

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Restriction of lentivirus in monkeys

29 September 2017

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Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3556581

Functional association of cyclophilin A with HIV-1 virions

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3556581

Specific incorporation of cyclophilin A into HIV-1 virions

29 September 2017

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Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution

29 September 2017

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Human infection by genetically diverse SIVSM-related HIV-2 in west Africa

29 September 2017

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Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors

29 September 2017

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The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity

21 January 2018

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Antiretroviral potential of human tripartite motif-5 and related proteins

21 January 2018

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Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.

21 January 2018

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Molecular recognition in the HIV-1 capsid/cyclophilin A complex

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/NSMB.1667

1 reference

Dimensions Publication ID

660728

1048994306

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660728

1 reference

1 reference

1 reference