Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase (Q27657793)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19833867%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase (English)

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10 February 2020

5

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10 February 2020

author name string

Shengying Li

1

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10 February 2020

Mani Raj Chaulagain

2

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10 February 2020

Allison R Knauff

3

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10 February 2020

Larissa M Podust

4

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10 February 2020

David H Sherman

6

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10 February 2020

language of work or name

English

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publication date

15 October 2009

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Proceedings of the National Academy of Sciences of the United States of America

10 February 2020

published in

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10 February 2020

volume

106

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10 February 2020

page(s)

18463-18468

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10 February 2020

issue

44

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In the light of directed evolution: pathways of adaptive protein evolution

10 February 2020

cites work

1 reference

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Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae

20 March 2017

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Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

20 March 2017

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

20 March 2017

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Chemo-enzymatic fluorination of unactivated organic compounds

20 March 2017

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Biologically inspired oxidation catalysis

29 September 2017

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A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis

29 September 2017

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Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry

29 September 2017

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The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

29 September 2017

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Cytochrome P450 monooxygenases: perspectives for synthetic application

29 September 2017

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Evolving strategies for enzyme engineering

29 September 2017

1 reference

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Cytochrome P450: nature's most versatile biological catalyst

29 September 2017

1 reference

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The use of substrate engineering in biohydroxylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774028

Understanding and exploiting C-H bond activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774028

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

29 September 2017

1 reference

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Libraries of hybrid proteins from distantly related sequences

29 September 2017

1 reference

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A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

29 September 2017

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Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774028

Organometallic chemistry: C-H activation.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Oxaziridine-mediated catalytic hydroxylation of unactivated 3 degrees C-H bonds using hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Thermal, Catalytic, Regiospecific Functionalization of Alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

A highly selective catalytic method for the oxidative functionalization of C-H bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

High turnover remote catalytic oxygenation of alkyl groups: how steric exclusion of unbound substrate contributes to high molecular recognition selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Fancy footwork in the sequence space shuffle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907203106

Chemospecific chromium[VI] catalyzed oxidation of C-H bonds at -40 degrees C1

21 January 2018

1 reference

12 December 2020

C-H bond functionalization in complex organic synthesis

1 reference

12 December 2020

Remote oxidation of steroids by photolysis of attached benzophenone groups

1 reference

12 December 2020

Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues

1 reference

12 December 2020

Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst

1 reference

12 December 2020

Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes

1 reference

12 December 2020

The Concept of Docking/Protecting Groups in Biohydroxylation

1 reference

12 December 2020

The concept of docking and protecting groups in biohydroxylation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0907203106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19833867%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19833867%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference