Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. (Q27658663)

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15 January 2020

title

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia (English)

1 reference

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Lysine methyltransferase 2A

15 January 2020

main subject

structural biology

0 references

1 reference

negative regulation of DNA methylation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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9

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15 January 2020

author name string

Tomasz Cierpicki

1

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15 January 2020

Laurie E Risner

2

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15 January 2020

Jolanta Grembecka

3

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15 January 2020

Stephen M Lukasik

4

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15 January 2020

Relja Popovic

5

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15 January 2020

Monika Omonkowska

6

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15 January 2020

David D Shultis

7

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15 January 2020

Nancy J Zeleznik-Le

8

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15 January 2020

publication date

13 December 2009

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Nature Structural & Molecular Biology

15 January 2020

published in

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15 January 2020

volume

17

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15 January 2020

issue

1

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15 January 2020

page(s)

62-68

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Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

15 January 2020

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20 March 2017

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20 March 2017

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Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains

20 March 2017

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MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

20 March 2017

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20 March 2017

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Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA

20 March 2017

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

20 March 2017

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Protein backbone angle restraints from searching a database for chemical shift and sequence homology

20 March 2017

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20 March 2017

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22 April 2017

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20 March 2017

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MLL translocations, histone modifications and leukaemia stem-cell development

20 March 2017

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Altered Hox expression and segmental identity in Mll-mutant mice

7 April 2017

1 reference

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

7 April 2017

1 reference

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MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

29 September 2017

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HOX deregulation in acute myeloid leukemia

29 September 2017

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

29 September 2017

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

29 September 2017

1 reference

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The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

29 September 2017

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When epigenetics kills: MLL fusion proteins in leukemia

29 September 2017

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MLL: how complex does it get?

29 September 2017

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Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.

29 September 2017

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Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

29 September 2017

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The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

29 September 2017

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Identification and characterization of the DNA binding domain of CpG-binding protein

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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Kinetic and thermodynamic evidence for flipping of a methyl-CpG binding domain on methylated DNA.

27 November 2018

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The MLL recombinome of acute leukemias

27 November 2018

1 reference

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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

27 November 2018

1 reference

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Quantitative NMR studies of high molecular weight proteins: application to domain orientation and ligand binding in the 723 residue enzyme malate synthase G.

27 November 2018

1 reference

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The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts.

27 November 2018

1 reference

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Function of the Polycomb protein is conserved in mice and flies.

27 November 2018

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Chromosomal aberration of the 11q23 locus in acute leukemia and frequency of MLL gene translocation: results in 378 adult patients

27 November 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNSMB.1714

31 March 2020

Identifiers

DOI

10.1038/NSMB.1714

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20010842%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 January 2020

1012801704

0 references

OpenCitations bibliographic resource ID

1570853

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1570853

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20010842%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference