Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 (Q27659655)

Gaya K Amarasinghe

4

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Diana R. Tomchick

Diana R Tomchick

9

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Daniel D. Billadeau

7

Martín E Fernández-Zapico

Daniel D Billadeau

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6

Martin E Fernandez-Zapico

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author name string

Bingke Yu

1

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Ilídio R S Martins

2

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Pilong Li

3

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Junko Umetani

5

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Michael K Rosen

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

10

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language of work or name

English

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publication date

22 January 2010

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published in

Cell

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volume

140

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page(s)

246-56

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issue

2

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cites work

1 reference

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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Dynamic personalities of proteins

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

7 April 2017

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Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins

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Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies

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Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

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Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction

29 September 2017

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Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer

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Vav-family proteins in T-cell signalling

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Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

29 September 2017

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Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

29 September 2017

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Internal dynamics control activation and activity of the autoinhibited Vav DH domain

29 September 2017

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Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

27 November 2018

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Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

27 November 2018

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NMR characterization of kinase p38 dynamics in free and ligand-bound forms

27 November 2018

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Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain

27 November 2018

1 reference

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Vav family GEFs link activated Ephs to endocytosis and axon guidance

27 November 2018

1 reference

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Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme.

27 November 2018

1 reference

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Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20141838

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2009.12.033

1 reference

4850318

4850318

1 reference

1 reference

1 reference