Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant (Q27659756)

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Christie G Brouillette

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Kris Conners

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Spencer Emtage

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Tarun Gheyi

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Jorg Hendle

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John F Hunt

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Hal A Lewis

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Frances Lu

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Irina I Protasevich

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Logan A Rodgers

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Rich Romero

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Stephen R Wasserman

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Patricia C Weber

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Diana Wetmore

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Feiyu F Zhang

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Xun Zhao

Protein Engineering Design and Selection

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publication date

May 2010

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published in

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volume

23

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issue

5

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page(s)

375-84

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The ABC protein turned chloride channel whose failure causes cystic fibrosis

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Attempts to characterize the NBD heterodimer of MRP1: transient complex formation involves Gly771 of the ABC signature sequence but does not enhance the intrinsic ATPase activity

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