Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance (Q27660267)

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English	Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance	scientific article

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20 January 2020

Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance (English)

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20 January 2020

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Visvaldas Kairys

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20 January 2020

Celia A. Schiffer

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Celia A Schiffer

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20 January 2020

author name string

Madhavi N L Nalam

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20 January 2020

Akbar Ali

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20 January 2020

Michael D Altman

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20 January 2020

G S Kiran Kumar Reddy

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20 January 2020

Sripriya Chellappan

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20 January 2020

Hong Cao

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20 January 2020

Michael K Gilson

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20 January 2020

Tariq M Rana

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publication date

17 March 2010

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20 January 2020

Journal of Virology

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20 January 2020

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10

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20 January 2020

5368-5378

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20 January 2020

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

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20 March 2017

BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

20 March 2017

Rational design of peptide-based HIV proteinase inhibitors

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20 March 2017

Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

1 reference

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20 March 2017

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

7 April 2017

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class∇

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

24 May 2017

Molecular basis of human immunodeficiency virus drug resistance: an update.

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29 September 2017

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863851

29 September 2017

TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

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29 September 2017

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor

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29 September 2017

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

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29 September 2017

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

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29 September 2017

The HIV-1 protease as a therapeutic target for AIDS

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29 September 2017

L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor

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2 June 2018

Combating susceptibility to drug resistance: lessons from HIV-1 protease.

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27 November 2018

Covariation of amino acid positions in HIV-1 protease

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27 November 2018

Evaluation of the substrate envelope hypothesis for inhibitors of HIV-1 protease

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The not-so-great escape

1 reference

https://pubmed.ncbi.nlm.nih.gov/20237088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV Drug Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20237088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.02531-09

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20 January 2020

1 reference

Europe PubMed Central

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20 January 2020

1 reference

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20 January 2020

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