Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin (Q27661904)

17

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Lewis C. Cantley

object named as

Lewis C Cantley

15

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Dennis J. Selkoe

20

object named as

Dennis J Selkoe

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author name string

Malcolm A Leissring

1

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Enrico Malito

2

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Lael Reinstatler

4

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Tomoko Sahara

5

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Samer O Abdul-Hay

6

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Shakeel Choudhry

7

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Ghulam M Maharvi

8

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Abdul H Fauq

9

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Malwina Huzarska

10

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Philip S May

11

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Sungwoon Choi

12

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Todd P Logan

13

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Benjamin E Turk

14

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Marika Manolopoulou

16

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Ross L Stein

18

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Gregory D Cuny

Creative Commons Attribution 4.0 International

19

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language of work or name

English

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publication date

7 May 2010

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published in

PLOS One

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volume

5

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page(s)

e10504

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issue

5

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copyright license

start time

7 May 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma

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Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

29 September 2017

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

29 September 2017

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Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Binding and degradation of 125I-insulin by rat hepatocytes

29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

27 November 2018

1 reference

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Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

27 November 2018

1 reference

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

27 November 2018

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Synthesis and characterization of insulin-fluorescein derivatives for bioanalytical applications.

27 November 2018

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Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

27 November 2018

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Degradation of intraendosomal insulin by insulin-degrading enzyme without acidification

27 November 2018

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12 December 2020

Enzyme target to latch on to

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12 December 2020

The role of insulinase and insulinase-inhibitors

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12 December 2020

Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells

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Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria

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Effect of insulinase-inhibitor on hypoglycemic action of insulin

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12 December 2020

Insulinase, insulinase-inhibitors, and diabetes mellitus

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12 December 2020

Peptide hydroxamic acids as inhibitors of thermolysin

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12 December 2020